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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-7-21
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pubmed:abstractText |
GATA-3 is expressed at higher levels in CD4 than in CD8 SP thymocytes. Here we show that upregulation of GATA-3 expression in DP thymocytes is triggered by TCR stimulation, and the extent of upregulation correlates with the strength of the TCR signal. Overexpression of GATA-3 or a partial GATA-3 agonist during positive selection inhibits CD8 SP cell development but is not sufficient to divert class I-restricted T cell precursors to the CD4 lineage. Conversely, expression of the GATA-3 antagonist ROG or of a GATA-3 siRNA hairpin markedly enhances development of CD8 SP cells and reduces CD4 SP development. We propose that GATA-3 contributes to linking the TCR signal strength to the differentiation program of CD4 and CD8 thymocytes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83-94
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pubmed:dateRevised |
2010-7-15
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pubmed:meshHeading |
pubmed-meshheading:12871641-Animals,
pubmed-meshheading:12871641-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12871641-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12871641-Cell Differentiation,
pubmed-meshheading:12871641-Cell Lineage,
pubmed-meshheading:12871641-DNA-Binding Proteins,
pubmed-meshheading:12871641-GATA3 Transcription Factor,
pubmed-meshheading:12871641-Mice,
pubmed-meshheading:12871641-Mice, Inbred C57BL,
pubmed-meshheading:12871641-Organ Culture Techniques,
pubmed-meshheading:12871641-Receptors, Antigen, T-Cell,
pubmed-meshheading:12871641-Thymus Gland,
pubmed-meshheading:12871641-Trans-Activators
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pubmed:year |
2003
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pubmed:articleTitle |
GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation.
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pubmed:affiliation |
Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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