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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-7-21
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pubmed:abstractText |
Estrogen potentiates behavioral sensitization to cocaine in the female rat by mechanisms that remain undetermined. In this study, functional receptor autoradiography was used to investigate estrogen modulation of D2/D3 receptor-induced G protein activation in components of the reward pathway of female rats treated acutely and repeatedly with cocaine. Rats were ovariectomized and given an empty (OVX group) or estradiol benzoate-filled (OVX-EB group) implant. After a week, animals received a daily saline or cocaine injection (15 mg/kg, i.p.) for 5 days, and again on day 13. Animals were killed, and brains were removed and cryosectioned. D2/D3-stimulated [35S]guanosine 5'-(gamma-thio) triphosphate (GTPgammaS) binding was assessed in the cingulate cortex area 2 (Cg2), striatum (STR), nucleus accumbens (NAc) and ventral tegmental area (VTA). OVX-EB rats showed more [35S]GTPgammaS binding in the Cg2 and lower binding in the VTA than OVX rats; in the VTA this effect was reversed by a single cocaine injection. Repeated cocaine administration had opposite effects in OVX and OVX-EB rats. [35S]GTPgammaS binding was decreased in the Cg2, NAc and STR of OVX-EB rats, and increased in OVX rats. The present results support the hypothesis that cocaine-induced changes in D2/D3 receptor activation are regulated by estrogen. These data suggest that changes in D2/D3 receptor function represent one mechanism by which estrogen regulates behavioral sensitization to cocaine.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Uptake Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Drd3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Implants,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine 5'-O-(3-Thiotriphosphate),
http://linkedlifedata.com/resource/pubmed/chemical/Quinpirole,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D3,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfur Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/estradiol 3-benzoate
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-3042
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
405-12
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12871581-Animals,
pubmed-meshheading:12871581-Autoradiography,
pubmed-meshheading:12871581-Behavior, Animal,
pubmed-meshheading:12871581-Binding, Competitive,
pubmed-meshheading:12871581-Brain,
pubmed-meshheading:12871581-Cocaine,
pubmed-meshheading:12871581-Dopamine Agonists,
pubmed-meshheading:12871581-Dopamine Uptake Inhibitors,
pubmed-meshheading:12871581-Drug Administration Schedule,
pubmed-meshheading:12871581-Drug Implants,
pubmed-meshheading:12871581-Estradiol,
pubmed-meshheading:12871581-Estrogens,
pubmed-meshheading:12871581-Female,
pubmed-meshheading:12871581-GTP-Binding Proteins,
pubmed-meshheading:12871581-Guanosine 5'-O-(3-Thiotriphosphate),
pubmed-meshheading:12871581-Ovariectomy,
pubmed-meshheading:12871581-Quinpirole,
pubmed-meshheading:12871581-Rats,
pubmed-meshheading:12871581-Rats, Sprague-Dawley,
pubmed-meshheading:12871581-Receptors, Dopamine D2,
pubmed-meshheading:12871581-Receptors, Dopamine D3,
pubmed-meshheading:12871581-Reward,
pubmed-meshheading:12871581-Sulfur Radioisotopes
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pubmed:year |
2003
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pubmed:articleTitle |
Estrogen-dependent alterations in D2/D3-induced G protein activation in cocaine-sensitized female rats.
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pubmed:affiliation |
Laboratory of Neuroendocrinology, Department of Physiology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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