| pubmed-article:12871215 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C0024202 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C0162597 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C0035253 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C1317973 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C0183683 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C0344211 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C1521721 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:12871215 | lifeskim:mentions | umls-concept:C1171411 | lld:lifeskim |
| pubmed-article:12871215 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12871215 | pubmed:dateCreated | 2003-7-21 | lld:pubmed |
| pubmed-article:12871215 | pubmed:abstractText | Little is known about the homeostatic mechanisms by which the levels of peripheral lymphocytes are maintained. The survival of naïve T cells in vivo must be maintained by some factors that have not been characterized in an in vitro culture system. In this study, we established a culture system of stromal cells derived from murine lymph nodes and investigated the action of the stromal cells in supporting the survival of resting T cells in vitro. Most of the T cells cocultured with the stromal cells did not die, and the supernatant of cultured stromal cells increase the viability of T cells. This T-cell survival-supporting activity was maintained for more than 7 days. Although interleukin (IL)-4, IL-6, IL-7, and interferon-beta also rescued peripheral T cells from spontaneous cell death, medium-soluble and heat-sensitive factor(s) derived from the stromal cells supported the survival of T cells more effectively and for a longer time than did these cytokines. T cells maintained in the culture system with the stromal cells appeared to remain in a resting G0/G1 state and did not show remarkable DNA synthesis. From these results, it is presumed that some soluble factor(s) other than the tested cytokines that have been identified as supporting T-cell survival are produced from lymph node stromal cells. These factor(s) play an important role in maintenance of resting T cells. | lld:pubmed |
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| pubmed-article:12871215 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12871215 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12871215 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12871215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12871215 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12871215 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12871215 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:12871215 | pubmed:author | pubmed-author:NakashimaIzum... | lld:pubmed |
| pubmed-article:12871215 | pubmed:author | pubmed-author:WuJianghongJ | lld:pubmed |
| pubmed-article:12871215 | pubmed:author | pubmed-author:SuzukiHaruhik... | lld:pubmed |
| pubmed-article:12871215 | pubmed:author | pubmed-author:ZhouYan-WenYW | lld:pubmed |
| pubmed-article:12871215 | pubmed:author | pubmed-author:HayakawaAkemi... | lld:pubmed |
| pubmed-article:12871215 | pubmed:author | pubmed-author:AritakeSayoko... | lld:pubmed |
| pubmed-article:12871215 | pubmed:author | pubmed-author:Tri... | lld:pubmed |
| pubmed-article:12871215 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12871215 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:12871215 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12871215 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12871215 | pubmed:pagination | 496-503 | lld:pubmed |
| pubmed-article:12871215 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12871215 | pubmed:meshHeading | pubmed-meshheading:12871215... | lld:pubmed |
| pubmed-article:12871215 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12871215 | pubmed:articleTitle | Murine lymph node-derived stromal cells effectively support survival but induce no activation/proliferation of peripheral resting T cells in vitro. | lld:pubmed |
| pubmed-article:12871215 | pubmed:affiliation | Departments of Immunology and Equipment Center for Research and Education, Nagoya University Graduate School of Medicine, Nagoya, Japan. | lld:pubmed |
| pubmed-article:12871215 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12871215 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12871215 | lld:pubmed |
