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pubmed-article:12870845pubmed:abstractTextDNA detection is usually performed using fluorescence probes. Using a DNA oligomer stained with the widely used dye 1,1'-[1,3-propanediylbis[(dimethylimino)-3,1-propanediyl]]bis[4-[(3-methyl-2(3H)-benzoxazolylidene)methyl]]-quinolinum tetraiodide (YOYO-1), we show that a substrate containing silver particles can lead to a greater than 10-fold increase in the fluorescence intensity. Proximity to silver particles also increases the photostability of YOYO-1-DNA. These results suggest that substrates or gels containing silver particles may be used for increased sensitivity in DNA detection.lld:pubmed
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pubmed-article:12870845pubmed:dateRevised2011-5-4lld:pubmed
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pubmed-article:12870845pubmed:articleTitleIncreased intensities of YOYO-1-labeled DNA oligomers near silver particles.lld:pubmed
pubmed-article:12870845pubmed:affiliationDepartment of Biochemistry and Molecular Biology, Center for Fluorescence Spectroscopy, School of Medicine, University of Maryland at Baltimore, Baltimore, MD 21201, USA. cfs@cfs.umbi.umd.edulld:pubmed
pubmed-article:12870845pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12870845pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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