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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5631
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pubmed:dateCreated |
2003-7-18
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pubmed:abstractText |
In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressful life events on depression. Individuals with one or two copies of the short allele of the 5-HT T promoter polymorphism exhibited more depressive symptoms, diagnosable depression, and suicidality in relation to stressful life events than individuals homozygous for the long allele. This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1095-9203
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pubmed:author |
pubmed-author:BraithwaiteAntonyA,
pubmed-author:CaspiAvshalomA,
pubmed-author:CraigIan WIW,
pubmed-author:HarringtonHonaLeeH,
pubmed-author:MartinJudyJ,
pubmed-author:McClayJosephJ,
pubmed-author:MillJonathanJ,
pubmed-author:MoffittTerrie ETE,
pubmed-author:PoultonRichieR,
pubmed-author:SugdenKarenK,
pubmed-author:TaylorAlanA
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
301
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
386-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12869766-Adult,
pubmed-meshheading:12869766-Alleles,
pubmed-meshheading:12869766-Carrier Proteins,
pubmed-meshheading:12869766-Child,
pubmed-meshheading:12869766-Child Abuse,
pubmed-meshheading:12869766-Depression,
pubmed-meshheading:12869766-Depressive Disorder,
pubmed-meshheading:12869766-Disease Susceptibility,
pubmed-meshheading:12869766-Female,
pubmed-meshheading:12869766-Genetic Predisposition to Disease,
pubmed-meshheading:12869766-Heterozygote,
pubmed-meshheading:12869766-Homozygote,
pubmed-meshheading:12869766-Humans,
pubmed-meshheading:12869766-Longitudinal Studies,
pubmed-meshheading:12869766-Male,
pubmed-meshheading:12869766-Membrane Glycoproteins,
pubmed-meshheading:12869766-Membrane Transport Proteins,
pubmed-meshheading:12869766-Monoamine Oxidase,
pubmed-meshheading:12869766-Nerve Tissue Proteins,
pubmed-meshheading:12869766-Polymorphism, Genetic,
pubmed-meshheading:12869766-Probability,
pubmed-meshheading:12869766-Promoter Regions, Genetic,
pubmed-meshheading:12869766-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:12869766-Stress, Psychological,
pubmed-meshheading:12869766-Suicide, Attempted
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pubmed:year |
2003
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pubmed:articleTitle |
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.
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pubmed:affiliation |
Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, PO80 De Crespigny Park, London, SE5 8AF, UK.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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