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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5631
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pubmed:dateCreated |
2003-7-18
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pubmed:abstractText |
The human-specific bacterial pathogen Neisseria meningitidis is a major cause of sepsis and/or meningitis. The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation. Transgenic mice expressing human CD46 were susceptible to meningococcal disease, because bacteria crossed the blood-brain barrier in these mice. Development of disease was more efficient with piliated bacteria after intranasal, but not intraperitoneal, challenge of CD46 transgenic mice, suggesting that human CD46 facilitates pilus-dependent interactions at the epithelial mucosa. Hence, the human CD46 transgenic mice model is a potentially useful tool for studying pathogenesis and for vaccine development against meningococcal disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
301
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
373-5
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:12869763-Animals,
pubmed-meshheading:12869763-Anti-Bacterial Agents,
pubmed-meshheading:12869763-Antigens, CD,
pubmed-meshheading:12869763-Antigens, CD46,
pubmed-meshheading:12869763-Bacteremia,
pubmed-meshheading:12869763-Blood-Brain Barrier,
pubmed-meshheading:12869763-Cerebrospinal Fluid,
pubmed-meshheading:12869763-Colony Count, Microbial,
pubmed-meshheading:12869763-Disease Models, Animal,
pubmed-meshheading:12869763-Fimbriae, Bacterial,
pubmed-meshheading:12869763-Humans,
pubmed-meshheading:12869763-Membrane Glycoproteins,
pubmed-meshheading:12869763-Meningitis, Meningococcal,
pubmed-meshheading:12869763-Meningococcal Infections,
pubmed-meshheading:12869763-Mice,
pubmed-meshheading:12869763-Mice, Inbred C57BL,
pubmed-meshheading:12869763-Mice, Transgenic,
pubmed-meshheading:12869763-Nasopharynx,
pubmed-meshheading:12869763-Neisseria meningitidis
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pubmed:year |
2003
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pubmed:articleTitle |
CD46 in meningococcal disease.
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pubmed:affiliation |
Microbiology and Tumor Biology Center, Nobels väg 16, Box 280, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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