Linked Life Data

12869760

Source:http://linkedlifedata.com/resource/pubmed/id/12869760

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5631
pubmed:dateCreated
2003-7-18
pubmed:abstractText
Mice in which all members of the Hox10 or Hox11 paralogous group are disrupted provide evidence that these Hox genes are involved in global patterning of the axial and appendicular skeleton. In the absence of Hox10 function, no lumbar vertebrae are formed. Instead, ribs project from all posterior vertebrae, extending caudally from the last thoracic vertebrae to beyond the sacral region. In the absence of Hox11 function, sacral vertebrae are not formed and instead these vertebrae assume a lumbar identity. The redundancy among these paralogous family members is so great that this global aspect of Hox patterning is not apparent in mice that are mutant for five of the six paralogous alleles.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
18
pubmed:volume
301
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
363-7
pubmed:dateRevised
2007-3-19
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton.
pubmed:affiliation
Howard Hughes Medical Institute and University of Utah, Salt Lake City, UT 84112, USA.
pubmed:publicationType
Journal Article