Linked Life Data

12868658

Source:http://linkedlifedata.com/resource/pubmed/id/12868658

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2003-7-18
pubmed:abstractText
The type IV secretion system encoded by the cag pathogenicity island of Helicobacter pylori is recognized as a major virulence determinant, governing the translocation of the CagA protein to eukaryotic cells. Despite the presence of 18 genes within the cag pathogenicity island which are essential for this process, several homologues encoding basic functions of a type IV secretion apparatus, such as a virB8 homologue, are still missing. We show here the presence of conserved VirB8 motifs in the cag-encoded apparatus protein HP530 and demonstrate that this protein adopts in E. coli a transmembrane topology similar to VirB8 and its homologues. Thus, we propose that HP530 is a type IV secretion component homologous to VirB8.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1438-4221
pubmed:author
pubmed:issnType
Print
pubmed:volume
293
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
213-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Topological analysis of a putative virB8 homologue essential for the cag type IV secretion system in Helicobacter pylori.
pubmed:affiliation
Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität, München, Germany.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't