Linked Life Data

12867154

Source:http://linkedlifedata.com/resource/pubmed/id/12867154

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2003-7-17
pubmed:abstractText
Antlers grow rapidly through the coordinated development of both osseocartilage and skin (velvet). The regional patterns of cell division in these two compartments were assessed by immunochemical detection of proliferating cell nuclear antigen (PCNA) in antlers from one-year-old red deer. The whole antler integument was in a state of growth and/or renewal, particularly the keratinocytes of the basal cell layer of the epidermis near the tip, and hair bulbs and sebaceous glands. More proximally, a zone of weaker mitotic activity was detected. Within the osseocartilagenous compartment, rapid mitosis was particularly apparent within the distal mesenchyme, visible as a dome-shaped band of staining. Mitotic activity of chondrocytes and osteoblasts was more extensive in peripheral areas of developing bone than in the centre. We conclude that the antler tip is the site of most active epidermal growth, and hypothesise that other mechanisms in addition to mechanical stretching play a role in growth of the integument.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1065-6995
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
625-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Mitotic activity in the growing red deer antler.
pubmed:affiliation
Biochemistry and Molecular Biology, School of Biological Sciences, University of Auckland, Thomas Building, 3A Symonds Street, Auckland, New Zealand.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't