Source:http://linkedlifedata.com/resource/pubmed/id/12866378
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2003-7-17
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| pubmed:abstractText |
We immunohistochemically evaluated 94 cases of urothelial carcinoma (UC) of the urinary bladder for the expression of caveolin (Cav)-1 and Cav-2. Neither benign urothelium present in 22 cases nor flat carcinoma in situ present in 10 cases stained for Cav-1 or Cav-2. Thirty-five (37%) of 94 cases and 45 (51%) of 89 cases of UC stained positively for Cav-1 and Cav-2, respectively. The percentages of positive cases for Cav-1 in grades 1, 2, and 3 tumors were 0% (0/6), 0% (0/25), and 56% (35/63), respectively (P < .001), and for Cav-2, 0% (0/6), 13% (3/23), and 70% (42/60), respectively (P < .001). Multivariate analysis showed no significant correlation between tumor stage and Cav-1 or Cav-2 expression after correction for tumor grade. Eighty-two percent (14/17) of cases with squamous differentiation were positive for Cav-1 compared with 43% (20/46) of grade 3 tumors without squamous differentiation (P < .001). These results indicate a positive correlation of the expression of Cav-1 and Cav-2 with tumor grade and squamous features of UC and suggest that Cav-1 and Cav-2 be studied further for a possible role in tumor progression and squamous differentiation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CAV1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caveolin 1,
http://linkedlifedata.com/resource/pubmed/chemical/Caveolin 2,
http://linkedlifedata.com/resource/pubmed/chemical/Caveolins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0002-9173
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
120
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
93-100
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12866378-Adult,
pubmed-meshheading:12866378-Aged,
pubmed-meshheading:12866378-Aged, 80 and over,
pubmed-meshheading:12866378-Carcinoma, Squamous Cell,
pubmed-meshheading:12866378-Carcinoma, Transitional Cell,
pubmed-meshheading:12866378-Carcinoma in Situ,
pubmed-meshheading:12866378-Caveolin 1,
pubmed-meshheading:12866378-Caveolin 2,
pubmed-meshheading:12866378-Caveolins,
pubmed-meshheading:12866378-Cell Transformation, Neoplastic,
pubmed-meshheading:12866378-Female,
pubmed-meshheading:12866378-Humans,
pubmed-meshheading:12866378-Immunohistochemistry,
pubmed-meshheading:12866378-Male,
pubmed-meshheading:12866378-Middle Aged,
pubmed-meshheading:12866378-Neoplasm Invasiveness,
pubmed-meshheading:12866378-Tumor Markers, Biological,
pubmed-meshheading:12866378-Urinary Bladder Neoplasms,
pubmed-meshheading:12866378-Urothelium
|
| pubmed:year |
2003
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| pubmed:articleTitle |
Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation.
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| pubmed:affiliation |
Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|