Linked Life Data

12865171

Source:http://linkedlifedata.com/resource/pubmed/id/12865171

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-7-16
pubmed:abstractText
Pyrogenic treatment with lipopolysaccharide (LPS) or interleukin-6 (IL-6) induces nuclear STAT3 translocation in the vascular organ of the laminae terminalis (OVLT) and the subfornical organ (SFO). STAT3 immunohistochemistry was combined with the detection of marker proteins (glial, neuronal, endothelial) and the nuclear DAPI stain to determine the phenotype of responding cells. At time points with high pyrogen-induced IL-6 plasma levels, nuclear STAT3 signals were co-localized with an astrocytic cell marker. IL-6 might therefore mediate genomic activation of OVLT/SFO astrocytes during LPS-induced fever.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
980
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Interleukin-6 mediates lipopolysaccharide-induced nuclear STAT3 translocation in astrocytes of rat sensory circumventricular organs.
pubmed:affiliation
Institute of Veterinary-Physiology, Justus-Liebig-University Giessen, Frankfurter Strasse 100, D-35392 Giessen, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't