Linked Life Data

12865090

Source:http://linkedlifedata.com/resource/pubmed/id/12865090

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2003-7-16
pubmed:abstractText
Synthetic nitric oxide donors are known to protect the gastric mucosa from damage and dietary nitrate is known to release NO in the stomach. Mast cells have been found to be involved in gastric mucosal damage in humans or in rodents, and recent studies have pointed out the possibility of nitric oxide from endogenous or exogenous origin to modulate mast cell reactivity. This study aimed to determine whether the protective effect afforded by dietary nitrate against gastric mucosal damage was linked to mast cell stabilization. Mast cell involvement in iodoacetamide-induced gastritis was investigated in rats receiving oral administration of iodoacetamide together with the mast cell stabilizer doxantrazole (ip) or its solvent. The effects of dietary nitrate on mast cells during gastritis were investigated in rats receiving iodoacetamide orally, associated or not with KNO3. Control groups were given water instead of iodoacetamide either with or without KNO3, doxantrazole or its solvent. After sacrifice, blood samples were taken to determine RMCP II serum level and the stomach was resected in order to determine myeloperoxidase (MPO) activity and mucosal mast cell (MMC) number. Iodoacetamide significantly increased gastric MPO activity but did not modify RMCP II serum level or MMC number. Doxantrazole and KNO3 significantly reduced iodoacetamide-induced increase in gastric MPO activity, increased MMC number, and decreased RMCP II serum level in basal conditions. Only doxantrazole was able to modify all parameters under inflammatory conditions. These results suggest that nitric oxide released by dietary nitrate in the stomach stabilizes mast cells in basal conditions but exerts its protective effect against experimental gastritis through other pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1505-16
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12865090-Administration, Oral, pubmed-meshheading:12865090-Animals, pubmed-meshheading:12865090-Chymases, pubmed-meshheading:12865090-Diet, pubmed-meshheading:12865090-Enzyme Inhibitors, pubmed-meshheading:12865090-Gastric Mucosa, pubmed-meshheading:12865090-Gastritis, pubmed-meshheading:12865090-Iodoacetamide, pubmed-meshheading:12865090-Male, pubmed-meshheading:12865090-Mast Cells, pubmed-meshheading:12865090-Models, Animal, pubmed-meshheading:12865090-Nitrates, pubmed-meshheading:12865090-Nitric Oxide, pubmed-meshheading:12865090-Peroxidase, pubmed-meshheading:12865090-Potassium Compounds, pubmed-meshheading:12865090-Rats, pubmed-meshheading:12865090-Rats, Wistar, pubmed-meshheading:12865090-Serine Endopeptidases, pubmed-meshheading:12865090-Thioxanthenes, pubmed-meshheading:12865090-Xanthones
pubmed:year
2003
pubmed:articleTitle
Effect of dietary nitric oxide on gastric mucosal mast cells in absence or presence of an experimental gastritis in rats.
pubmed:affiliation
Neurogastroenterology & Nutrition Unit, Institut National de la Recherche Agronomique, 180 chemin de Tournefeuille, B.P. 3, 31931 Toulouse, F-31931, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't