Linked Life Data

12860283

Source:http://linkedlifedata.com/resource/pubmed/id/12860283

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-7-15
pubmed:abstractText
The DRH is an inbred rat strain highly resistant to chemically induced hepatocarcinogenesis. Two clusters of resistance loci Drh1 and Drh2 on chromosome 1 and 4 yield strong resistance to the formation of enzyme-altered foci and their progression. To evaluate the effect of enhanced cell proliferation in the progression stage, a partial hepatectomy (PH) was carried out in (DRH x F344)F1 rats 8 weeks after the start of 3'-Me-DAB administration. The incidence of liver cancer in the PH-F1 rats was equivalent to that in the F344 rats, although the number of tumors per rat was much lower. In contrast, the F1 rats without PH rarely developed cancers. Such modulation was not due to the loss of the resistance allele, since none of 18 hepatocellular carcinomas in PH-F1 rats showed allelic imbalance at Drhl and Drh2.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
196
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Modulation of genetic resistance to hepatocarcinogenesis in DRH rats by partial hepatectomy.
pubmed:affiliation
Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho. Sakyo-ku, Kyoto 606-8501, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't