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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-7-15
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pubmed:abstractText |
Glucose-dependent insulinotropic peptide (GIP) is known to modulate alkaline phosphatase activity and collagen type I message in osteoblastic-like cells. GIP effects on cell proliferation are not known. We report that GIP dose dependently stimulated 3H-thymidine incorporation in the osteoblastic-like cell line MG-63. Furthermore, GIP increased message and secretion of transforming growth factor beta (TGF-beta), an agent known to regulate osteoblastic proliferation and differentiation. However, when GIP was added to MG-63 cells concurrently with a TGF-beta neutralizing antibody, there was no effect on 3H-thymidine incorporation in these cells. These data demonstrate that GIP stimulates osteoblastic-like cell proliferation but that this effect is not mediated by TGF-beta.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon-Like Peptide 1,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon-Like Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidine,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/glucagon-like peptide 1 (7-36)amide
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0196-9781
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
611-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12860206-Alkaline Phosphatase,
pubmed-meshheading:12860206-Blotting, Northern,
pubmed-meshheading:12860206-Cell Differentiation,
pubmed-meshheading:12860206-Cell Division,
pubmed-meshheading:12860206-Cell Line, Tumor,
pubmed-meshheading:12860206-Collagen,
pubmed-meshheading:12860206-Dose-Response Relationship, Drug,
pubmed-meshheading:12860206-Glucagon,
pubmed-meshheading:12860206-Glucagon-Like Peptide 1,
pubmed-meshheading:12860206-Glucagon-Like Peptides,
pubmed-meshheading:12860206-Glucose,
pubmed-meshheading:12860206-Humans,
pubmed-meshheading:12860206-Insulin,
pubmed-meshheading:12860206-Osteoblasts,
pubmed-meshheading:12860206-Peptide Fragments,
pubmed-meshheading:12860206-Peptides,
pubmed-meshheading:12860206-RNA,
pubmed-meshheading:12860206-Thymidine,
pubmed-meshheading:12860206-Transforming Growth Factor beta
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pubmed:year |
2003
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pubmed:articleTitle |
Glucose-dependent insulinotropic peptide stimulates proliferation and TGF-beta release from MG-63 cells.
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pubmed:affiliation |
Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta 30912, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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