rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
7
|
pubmed:dateCreated |
2003-7-14
|
pubmed:abstractText |
Wegener's granulomatosis (WG) is an idiopathic inflammatory condition characterized by upper and lower airway involvement and often renal dysfunction. Sites of tissue injury include pleomorphic cell populations, and classically mononuclear cell infiltrates that may form granulomas. Vascular inflammation (i.e., vasculitis) is often but not always present. Because CCR5 and its ligands influence mononuclear cell trafficking, we sought to identify their expression in pulmonary lesions and to determine whether genetic variations in genes for CCR5 and its ligands influence susceptibility to WG.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0315-162X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
30
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1541-7
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:12858455-Antibodies, Antineutrophil Cytoplasmic,
pubmed-meshheading:12858455-Chemokine CCL3,
pubmed-meshheading:12858455-Chemokine CCL4,
pubmed-meshheading:12858455-Chemokine CCL5,
pubmed-meshheading:12858455-DNA,
pubmed-meshheading:12858455-Female,
pubmed-meshheading:12858455-Genetic Predisposition to Disease,
pubmed-meshheading:12858455-Humans,
pubmed-meshheading:12858455-Macrophage Inflammatory Proteins,
pubmed-meshheading:12858455-Male,
pubmed-meshheading:12858455-Polymerase Chain Reaction,
pubmed-meshheading:12858455-Polymorphism, Genetic,
pubmed-meshheading:12858455-Receptors, CCR5,
pubmed-meshheading:12858455-Wegener Granulomatosis
|
pubmed:year |
2003
|
pubmed:articleTitle |
Relative importance of CCR5 and antineutrophil cytoplasmic antibodies in patients with Wegener's granulomatosis.
|
pubmed:affiliation |
Department of Rheumatic and Immunologic Diseases, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|