Linked Life Data

12858054

Source:http://linkedlifedata.com/resource/pubmed/id/12858054

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-7-14
pubmed:abstractText
Space flight produces changes in neuronal activity in the vestibular system. We studied the protein expression of the NMDA receptor subunit NR1 in the vestibular ganglia of rats exposed to microgravity for 17 days, beginning on postnatal day 8, as part of the NASA Neurolab mission. As a control, we studied the cochlear ganglia in the same way. NR1 expression in rats that had experienced microgravity (flight-FLT rats) was compared with that in two types of ground control. One control consisted of rats housed in regular cage conditions (VIV, vivarium); the other, asynchronous ground control (AGC), consisted of rats kept in cages similar to those used in flight (animal enclosure module, AEM), requiring no human care. After 8 days of flight, NR1 levels in the vestibular and cochlear neurons were similar in FLT, VIV and AGC rats. In contrast, 8 h after landing, the FLT and VIV animals showed similar, normal levels of NR1 staining, whereas the ganglia of the AGC animals displayed only very faint staining. Thus, microgravity did not modify NR1 expression in vestibular neurons. The lower levels of NR1 expression in the vestibular and cochlear neurons of AGC rats suggest an effect of confinement for 17 days in AEMs on the ground.
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
887-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Confinement but not microgravity alters NMDA NR1 receptor expression in rat inner ear ganglia.
pubmed:affiliation
INSERM U432, Université de Montpellier II, Place Bataillon, 34095 Montpellier, France. claudejd@univ-montp2-fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't