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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-7-14
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pubmed:abstractText |
Smad ubiquitin regulatory factor (Smurf) 1 binds to receptor-regulated Smads for bone morphogenetic proteins (BMPs) Smad1/5 and promotes their degradation. In addition, Smurf1 associates with transforming growth factor-beta type I receptor through the inhibitory Smad (I-Smad) Smad7 and induces their degradation. Herein, we examined whether Smurf1 negatively regulates BMP signaling together with the I-Smads Smad6/7. Smurf1 and Smad6 cooperatively induced secondary axes in Xenopus embryos. Using a BMP-responsive promoter-reporter construct in mammalian cells, we found that Smurf1 cooperated with I-Smad in inhibiting BMP signaling and that the inhibitory activity of Smurf1 was not necessarily correlated with its ability to bind to Smad1/5 directly. Smurf1 bound to BMP type I receptors via I-Smads and induced ubiquitination and degradation of these receptors. Moreover, Smurf1 associated with Smad1/5 indirectly through I-Smads and induced their ubiquitination and degradation. Smurf1 thus controls BMP signaling with and without I-Smads through multiple mechanisms.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-10458166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-10692396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-10854429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-11158580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-11163210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-11278251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-11319750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-11359933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-11376112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-11376113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-11389444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-11703946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-11739411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-1684739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-7849513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-8006002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-8682290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-9335505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-9335506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-9335507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-9393997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-9436979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-9449668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-9514869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-9670020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-9720756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-9748228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12857866-9759494
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Activin Receptors, Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SMURF1 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Smad6 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad6 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Smad7 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad7 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/TGF-beta type I receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1059-1524
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2809-17
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12857866-Activin Receptors, Type I,
pubmed-meshheading:12857866-Animals,
pubmed-meshheading:12857866-Bone Morphogenetic Proteins,
pubmed-meshheading:12857866-COS Cells,
pubmed-meshheading:12857866-Cells, Cultured,
pubmed-meshheading:12857866-DNA-Binding Proteins,
pubmed-meshheading:12857866-Embryo, Nonmammalian,
pubmed-meshheading:12857866-Models, Molecular,
pubmed-meshheading:12857866-Phosphorylation,
pubmed-meshheading:12857866-Protein Binding,
pubmed-meshheading:12857866-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12857866-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:12857866-Recombinant Proteins,
pubmed-meshheading:12857866-Signal Transduction,
pubmed-meshheading:12857866-Smad6 Protein,
pubmed-meshheading:12857866-Smad7 Protein,
pubmed-meshheading:12857866-Trans-Activators,
pubmed-meshheading:12857866-Ubiquitin-Protein Ligases,
pubmed-meshheading:12857866-Xenopus,
pubmed-meshheading:12857866-Xenopus Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads.
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pubmed:affiliation |
Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo 170-8455, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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