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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-7-14
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pubmed:abstractText |
A novel leucine-zipper gene, leucine zipper protein 2 (Luzp2), has been cloned as part of an aberrant deletion-fusion transcript in the chromosomal interval between Gas2 and Herc2 on mouse Chromosome 7 (Chr 7). Luzp2 is normally expressed only in brain and spinal cord. The human homolog of Luzp2 maps to Chr 11p13-11p14 by radiation-hybrid mapping and is deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome. Disruption of Luzp2 by gene targeting in mice did not result in any obvious abnormal phenotypes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0938-8990
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
323-34
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12856284-Amino Acid Sequence,
pubmed-meshheading:12856284-Animals,
pubmed-meshheading:12856284-Base Sequence,
pubmed-meshheading:12856284-Blotting, Northern,
pubmed-meshheading:12856284-Chromosome Deletion,
pubmed-meshheading:12856284-Chromosome Mapping,
pubmed-meshheading:12856284-Chromosomes, Human, Pair 11,
pubmed-meshheading:12856284-Cloning, Molecular,
pubmed-meshheading:12856284-DNA Mutational Analysis,
pubmed-meshheading:12856284-DNA Primers,
pubmed-meshheading:12856284-DNA-Binding Proteins,
pubmed-meshheading:12856284-Female,
pubmed-meshheading:12856284-Gene Expression Regulation, Developmental,
pubmed-meshheading:12856284-Gene Targeting,
pubmed-meshheading:12856284-Humans,
pubmed-meshheading:12856284-Leucine Zippers,
pubmed-meshheading:12856284-Male,
pubmed-meshheading:12856284-Mice,
pubmed-meshheading:12856284-Mice, Inbred C57BL,
pubmed-meshheading:12856284-Mice, Knockout,
pubmed-meshheading:12856284-Molecular Sequence Data,
pubmed-meshheading:12856284-Phenotype,
pubmed-meshheading:12856284-Polymerase Chain Reaction,
pubmed-meshheading:12856284-Radiation Hybrid Mapping,
pubmed-meshheading:12856284-Ribonuclease, Pancreatic,
pubmed-meshheading:12856284-Tumor Cells, Cultured,
pubmed-meshheading:12856284-WAGR Syndrome
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pubmed:year |
2003
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pubmed:articleTitle |
Cloning, functional study and comparative mapping of Luzp2 to mouse chromosome 7 and human chromosome 11p13-11p14.
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pubmed:affiliation |
Life Sciences Division, Oak Ridge National Laboratory, University of Tennessee, Graduate School of Genome Science and Technology, Oak Ridge, Tennessee, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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