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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2003-8-8
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pubmed:abstractText |
Mesangial cell hypertrophy is one of the earliest morphological abnormalities of diabetic nephropathy. We have previously shown that high glucose induces p27(Kip1) by a post-transcriptional mechanism and that mesangial cell hypertrophy depends on G(1)-phase arrest mediated by this CDK-inhibitor. However, it remains poorly understood how high glucose stimulates p27(Kip1) expression in mesangial cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1b protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0012-186X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1090-9
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:12856081-Animals,
pubmed-meshheading:12856081-Cell Cycle Proteins,
pubmed-meshheading:12856081-Cell Division,
pubmed-meshheading:12856081-Cells, Cultured,
pubmed-meshheading:12856081-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:12856081-Cyclin-Dependent Kinases,
pubmed-meshheading:12856081-DNA,
pubmed-meshheading:12856081-Glomerular Mesangium,
pubmed-meshheading:12856081-Glucose,
pubmed-meshheading:12856081-Hypertrophy,
pubmed-meshheading:12856081-Mice,
pubmed-meshheading:12856081-Mice, Knockout,
pubmed-meshheading:12856081-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:12856081-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:12856081-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12856081-Phosphorylation,
pubmed-meshheading:12856081-Transfection,
pubmed-meshheading:12856081-Tumor Suppressor Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Erk 1,2 phosphorylates p27(Kip1): Functional evidence for a role in high glucose-induced hypertrophy of mesangial cells.
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pubmed:affiliation |
Department of Medicine, University of Hamburg, University Hospital Eppendorf, 20246 Hamburg, Germany. Wolf@uke.uni-hamburg.de
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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