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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-7-11
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pubmed:abstractText |
Vascular endothelial growth factor (VEGF) is a potent angiogenic agent and plays a major role in tumor growth and metastases. We have previously reported the locoregional (i.p.) delivery of adenovirus-mediated antiangiogenic soluble FLT-1 (sFLT-1; a naturally encoded potent VEGF antagonist) gene therapy to inhibit VEGF action in a murine ovarian carcinoma model. This study was predicated on the fact that systemic delivery of sFLT-1 might allow an approach for therapy of disseminated tumor. The purpose of this study is to test the effects of i.v. delivered, adenovirus-mediated sFLT-1 on the survival duration in a murine ovarian tumor model and to evaluate the safety of i.v.-delivered versus i.p.-delivered adenovirus-mediated sFLT-1 in non-tumor-bearing mice.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FLT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Flt1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Luminescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myosin Heavy Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Nonmuscle Myosin Type IIB,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/nonmuscle myosin type IIB heavy...
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2701-10
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12855650-Adenoviridae,
pubmed-meshheading:12855650-Animals,
pubmed-meshheading:12855650-Cell Division,
pubmed-meshheading:12855650-Cell Line, Tumor,
pubmed-meshheading:12855650-Cell Survival,
pubmed-meshheading:12855650-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12855650-Extracellular Matrix Proteins,
pubmed-meshheading:12855650-Female,
pubmed-meshheading:12855650-Gene Therapy,
pubmed-meshheading:12855650-Genetic Vectors,
pubmed-meshheading:12855650-Green Fluorescent Proteins,
pubmed-meshheading:12855650-Humans,
pubmed-meshheading:12855650-Immunohistochemistry,
pubmed-meshheading:12855650-Liver,
pubmed-meshheading:12855650-Luminescent Proteins,
pubmed-meshheading:12855650-Mice,
pubmed-meshheading:12855650-Mice, SCID,
pubmed-meshheading:12855650-Microscopy, Fluorescence,
pubmed-meshheading:12855650-Myosin Heavy Chains,
pubmed-meshheading:12855650-Neoplasm Metastasis,
pubmed-meshheading:12855650-Neovascularization, Pathologic,
pubmed-meshheading:12855650-Nonmuscle Myosin Type IIB,
pubmed-meshheading:12855650-Ovarian Neoplasms,
pubmed-meshheading:12855650-Time Factors,
pubmed-meshheading:12855650-Vascular Endothelial Growth Factor Receptor-1
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pubmed:year |
2003
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pubmed:articleTitle |
Intravenous delivery of adenovirus-mediated soluble FLT-1 results in liver toxicity.
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pubmed:affiliation |
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and The Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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