Linked Life Data

12855187

Source:http://linkedlifedata.com/resource/pubmed/id/12855187

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-7-11
pubmed:abstractText
It is well established that early oligodendrocyte progenitors (OLPs) are induced by Sonic hedgehog (Shh) from the ventral ventricular zone throughout the entire neural axis. Here, we report that OLP cells can also be generated from the dorsal ventricular and subventricular zone in embryonic chicken midbrain at later stages. Concomitantly, a low level of Shh expression is detected in the adjacent ventricular and subventricular zones, implying that oligodendrogenesis in the dorsal midbrain is also regulated by Shh. In addition, Nkx2.2 and Olig2 are co-expressed in the same OLPs generated from the dorsal midbrain, suggesting that the dorsal oligodendrogenesis is similarly under the dual control of these two transcription factors as in the developing spinal cord.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
143
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
161-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Oligodendrocytes can be generated from the local ventricular and subventricular zones of embryonic chicken midbrain.
pubmed:affiliation
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't