Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-7-10
pubmed:abstractText
The family of Helicobacter cysteine-rich proteins (Hcp) constitutes one of the largest protein families that are specific for proteobacteria from the delta/epsilon subgroup. Most of the proteins belonging to this family have so far only been recognized on the genome level. To investigate the expression of Hcp proteins in vivo we analyzed titers of antibody against HcpA (HP0211), HcpB (HP0336), HcpC (HP1098), and HcpE (HP0235) in sera from 30 Helicobacter pylori-positive individuals and in a control group of six H. pylori-negative individuals. Significantly higher titers of antibody were observed for H. pylori-positive individuals (P < 0.00005). The highest and lowest titers were observed for HcpC (Delta mean = 1.06) and HcpB (Delta mean = 0.333), respectively. There is a clear correlation among anti-HcpA, -HcpC, and -HcpE immunoglobulin G titers in H. pylori-positive individuals (correlation > 0.7), but there is only a weak correlation for HcpB (correlation < 0.4). These results confirm that Hcp proteins are expressed by H. pylori under natural environmental conditions and that these proteins are recognized by the immune system of the host. The observed correlations are in agreement with the expected distribution of Hcp proteins among H. pylori strains. HcpA, HcpC, and HcpE are present in the genomes of strains 26695 and J99, whereas HcpB is absent from most strains. Since Hcp proteins are specific for H. pylori, immunological assays including Hcp proteins might be of value to detect H. pylori infection and perhaps to distinguish among different groups of H. pylori-positive patients.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12853383-10391848, http://linkedlifedata.com/resource/pubmed/commentcorrection/12853383-10438788, http://linkedlifedata.com/resource/pubmed/commentcorrection/12853383-10748053, http://linkedlifedata.com/resource/pubmed/commentcorrection/12853383-11777911, http://linkedlifedata.com/resource/pubmed/commentcorrection/12853383-11921447, http://linkedlifedata.com/resource/pubmed/commentcorrection/12853383-12023975, http://linkedlifedata.com/resource/pubmed/commentcorrection/12853383-12065478, http://linkedlifedata.com/resource/pubmed/commentcorrection/12853383-12427957, http://linkedlifedata.com/resource/pubmed/commentcorrection/12853383-2188975, http://linkedlifedata.com/resource/pubmed/commentcorrection/12853383-9252185, http://linkedlifedata.com/resource/pubmed/commentcorrection/12853383-9317022, http://linkedlifedata.com/resource/pubmed/commentcorrection/12853383-9596777
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1071-412X
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
542-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Detection of high titers of antibody against Helicobacter cysteine-rich proteins A, B, C, and E in Helicobacter pylori-infected individuals.
pubmed:affiliation
Biochemical Institute, University of Zürich, CH-8057 Zürich, Switzerland. mittl@bioc.unizh.ch
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't