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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2003-7-10
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pubmed:abstractText |
A solid-phase approach for the total synthesis of methyl carboxymycobactins 1a-d, with an on-resin cyclization leading to azopine 5 as the key step, was developed. The iron-affinity of these compounds was assessed by a competitive sulfoxine-binding assay, and antimycobacterial activity was tested against the growth of Mycobacterium avium.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2553-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12852964-Anti-Bacterial Agents,
pubmed-meshheading:12852964-Chromatography, High Pressure Liquid,
pubmed-meshheading:12852964-Cyclization,
pubmed-meshheading:12852964-Indicators and Reagents,
pubmed-meshheading:12852964-Iron,
pubmed-meshheading:12852964-Iron Chelating Agents,
pubmed-meshheading:12852964-Microbial Sensitivity Tests,
pubmed-meshheading:12852964-Mycobacterium avium Complex,
pubmed-meshheading:12852964-Oxazoles,
pubmed-meshheading:12852964-Spectrometry, Mass, Electrospray Ionization,
pubmed-meshheading:12852964-Spectrophotometry, Ultraviolet
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pubmed:year |
2003
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pubmed:articleTitle |
Solid-phase synthesis of methyl carboxymycobactin T 7 and analogues as potential antimycobacterial agents.
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pubmed:affiliation |
MetaPhore Pharmaceuticals, Inc., 1910 Innerbelt Business Center Drive, Saint Louis, MO 63114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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