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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2003-7-10
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pubmed:abstractText |
The protonation constants and the stability constants for the formation of copper (II) complex of the ligand [1,4,7] Triazecan-9-ol (L) were presented. Antitumor activity of CuL complex was reported. Preliminary pharmacological tests showed that it had antitumor activity against HXO-RB44 and BEL-7402 cell lines in vitro. Nuclei of [CuL]-stimulated BEL-7402 cells clearly exhibited condensation and break down into chromatin clumps typical of apoptosis. Also it exhibited perturbation effects to BEL-7402 cell lines cycle and further studies showed that it could cleave supercoiled DNA (pBR 322) to nicked and linear DNA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2469-72
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12852945-Antineoplastic Agents,
pubmed-meshheading:12852945-Apoptosis,
pubmed-meshheading:12852945-Bisbenzimidazole,
pubmed-meshheading:12852945-Cell Cycle,
pubmed-meshheading:12852945-Cell Line,
pubmed-meshheading:12852945-Coloring Agents,
pubmed-meshheading:12852945-Copper,
pubmed-meshheading:12852945-DNA, Neoplasm,
pubmed-meshheading:12852945-Drug Screening Assays, Antitumor,
pubmed-meshheading:12852945-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:12852945-Indicators and Reagents,
pubmed-meshheading:12852945-Ligands,
pubmed-meshheading:12852945-Organometallic Compounds,
pubmed-meshheading:12852945-Potentiometry
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pubmed:year |
2003
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pubmed:articleTitle |
Copper complex of hydroxyl-substituted triazamacrocyclic ligand and its antitumor activity.
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pubmed:affiliation |
Department of Chemistry, Wuhan University, Wuhan 430072, PR China. chemoliangf@yahoo.com.cn
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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