Source:http://linkedlifedata.com/resource/pubmed/id/12852200
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2003-7-10
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| pubmed:abstractText |
In adults, MeHg poisoning is characterized by damage to discrete anatomical areas of the brain (visual cortex, loss of neurons from the granule layer of the cerebellum). However, the immature central nervous system (CNS), which is extremely sensitive to MeHg neurotoxicity, shows a diffuse and widespread damage disorganization of cerebral cortex cytoarchitecture, disappearance of granule cells with narrowing of the molecular layer. While adverse effects have been unequivocally demonstrated in poisoning incidents in humans (visual abnormalities, sensory impairment of the extremities, cerebellar ataxia, hearing loss, muscle weakness, tremor and mental deterioration), the implications of lower level exposures, such as those occurring in fish-eating populations, are still controversial. The high affinity of MeHg for thiol groups makes proteins and peptides bearing cysteines the predominant targets for structural and functional modification by MeHg in all subcellular compartments.
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| pubmed:language |
ita
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0025-7818
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
94
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
183-91
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12852200-Adult,
pubmed-meshheading:12852200-Apoptosis,
pubmed-meshheading:12852200-Cells, Cultured,
pubmed-meshheading:12852200-Cerebellum,
pubmed-meshheading:12852200-Environmental Pollutants,
pubmed-meshheading:12852200-Female,
pubmed-meshheading:12852200-Fetus,
pubmed-meshheading:12852200-Humans,
pubmed-meshheading:12852200-Methylmercury Compounds,
pubmed-meshheading:12852200-Microtubules,
pubmed-meshheading:12852200-Necrosis,
pubmed-meshheading:12852200-Neurons,
pubmed-meshheading:12852200-Neurotoxins,
pubmed-meshheading:12852200-Neurotransmitter Agents,
pubmed-meshheading:12852200-Oxidative Stress,
pubmed-meshheading:12852200-Pregnancy,
pubmed-meshheading:12852200-Risk Assessment,
pubmed-meshheading:12852200-Synaptic Transmission,
pubmed-meshheading:12852200-Toxicology
|
| pubmed:articleTitle |
[In vitro models for the evaluation of the neurotoxicity of methylmercury. Current state of knowledge].
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| pubmed:affiliation |
Sezione di Medicina del Lavoro e Laboratorio di Tossicologia Industriale, Dipartimento di Clinica Medica, Nefrologia e Scienze della Prevenzione, Università di Parma, Via Gramsci 14, 43100 Parma, Italia.
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| pubmed:publicationType |
Journal Article,
English Abstract,
Review
|