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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-7-9
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pubmed:abstractText |
Exendin-4 (Ex4) is a potent and long-lasting agonist of glucagon-like peptide-1 (GLP-1), which has been previously found to stimulate pituitary-adrenal axis in the rat. Aim of the present study was to gain insight into the mechanism(s) involved in the Ex4-induced rise in the rat plasma concentrations of ACTH, aldosterone and corticosterone. Preliminary time- and dose-response studies showed that the maximum stimulating effect of Ex4 occurred within 1 or 2 h and at dose ranging from 0.5 to 2.0 nmol/100 g body weight. The GLP-1 receptor (GLP-1R) antagonist Ex(9-39) did not significantly affect ACTH, aldosterone and cortico-sterone responses to Ex4. Neither the administration of CRH and arginine vasopressin (AVP)-receptor antagonists nor adrenal demedullation prevented pituitary-adrenal axis responses to Ex4. The prolonged (4 or 6 days) suppression of the pituitary ACTH release by dexamethasone impaired corticosterone, but not aldosterone response to Ex4. The following conclusions are drawn: i) Ex4 stimulates rat pituitary-adrenal axis through receptors other than the classic GLP-1R; ii) neither CRH and AVP nor medullary catecholamines are involved in the Ex4-induced stimulation of ACTH release; iii) ACTH stimulation accounts for the rise in corticosterone plasma concentration; and iv) the aldosterone secretagogue effect of Ex4 occurs via a mechanism independent of the stimulation of either ACTH or medullary catecholamines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenocorticotropic Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Aldosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Arginine Vasopressin,
http://linkedlifedata.com/resource/pubmed/chemical/Corticosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Corticotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Hormone Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/alpha helical...,
http://linkedlifedata.com/resource/pubmed/chemical/exenatide,
http://linkedlifedata.com/resource/pubmed/chemical/glucagon-like peptide receptor,
http://linkedlifedata.com/resource/pubmed/chemical/vasopressin...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1107-3756
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
237-41
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pubmed:dateRevised |
2008-8-16
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pubmed:meshHeading |
pubmed-meshheading:12851724-Adrenal Cortex,
pubmed-meshheading:12851724-Adrenocorticotropic Hormone,
pubmed-meshheading:12851724-Aldosterone,
pubmed-meshheading:12851724-Animals,
pubmed-meshheading:12851724-Arginine Vasopressin,
pubmed-meshheading:12851724-Corticosterone,
pubmed-meshheading:12851724-Corticotropin-Releasing Hormone,
pubmed-meshheading:12851724-Dexamethasone,
pubmed-meshheading:12851724-Dose-Response Relationship, Drug,
pubmed-meshheading:12851724-Female,
pubmed-meshheading:12851724-Hormone Antagonists,
pubmed-meshheading:12851724-Peptides,
pubmed-meshheading:12851724-Pituitary-Adrenal System,
pubmed-meshheading:12851724-Rats,
pubmed-meshheading:12851724-Rats, Wistar,
pubmed-meshheading:12851724-Receptors, Glucagon,
pubmed-meshheading:12851724-Time Factors,
pubmed-meshheading:12851724-Venoms
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pubmed:year |
2003
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pubmed:articleTitle |
Exendin-4, a GLP-1 receptor agonist, stimulates pituitary-adrenocortical axis in the rat: Investigations into the mechanism(s) underlying Ex4 effect.
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pubmed:affiliation |
Department of Histology and Embryology, Karol Marcinkowski University of Medical Sciences, PL-60781 Poznan, Poland.
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pubmed:publicationType |
Journal Article
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