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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-7-9
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pubmed:abstractText |
We sought to investigate the relation between the Arg389Gly polymorphism in the human beta1-adrenergic receptor (ADRB1) gene and acute myocardial infarction (AMI). It was previously reported that augmented sympathetic activity might play an important role as a trigger of AMI by enhanced hemodynamic or mechanical forces through ADRB1 activation. Recently, a common polymorphism has been identified at amino acid position 389 (Arg or Gly) of the human ADRB1, within a region important for receptor-Gs protein coupling and subsequent agonist-stimulated adenylyl cyclase activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1097-6744
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pubmed:author |
pubmed-author:AkitaHozukaH,
pubmed-author:HayashiTakatoshiT,
pubmed-author:IwaiChikaoC,
pubmed-author:KajiyaTeishiT,
pubmed-author:KanazawaKenjiK,
pubmed-author:MatsudaYasuakiY,
pubmed-author:MiyamotoYoshitomoY,
pubmed-author:ShigaNobuyukiN,
pubmed-author:ShimizuMasakatsuM,
pubmed-author:TakaiEijiE,
pubmed-author:TerashimaMasahiroM,
pubmed-author:YokoyamaMitsuhiroM
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pubmed:issnType |
Electronic
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pubmed:volume |
146
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
106-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12851615-Aged,
pubmed-meshheading:12851615-Alleles,
pubmed-meshheading:12851615-Case-Control Studies,
pubmed-meshheading:12851615-Female,
pubmed-meshheading:12851615-Humans,
pubmed-meshheading:12851615-Male,
pubmed-meshheading:12851615-Middle Aged,
pubmed-meshheading:12851615-Myocardial Infarction,
pubmed-meshheading:12851615-Polymorphism, Genetic,
pubmed-meshheading:12851615-Receptors, Adrenergic, beta-1,
pubmed-meshheading:12851615-Statistics as Topic
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pubmed:year |
2003
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pubmed:articleTitle |
Arg389Gly polymorphism of the human beta1-adrenergic receptor in patients with nonfatal acute myocardial infarction.
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pubmed:affiliation |
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
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pubmed:publicationType |
Journal Article
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