Linked Life Data

12851479

Source:http://linkedlifedata.com/resource/pubmed/id/12851479

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-7-9
pubmed:abstractText
Many aspects of chromosome biology are fundamentally linked to events that occur during the DNA synthesis (S) phase of the cell cycle. The DNA must be duplicated once, and once exactly, each S phase. Local chromatin structure must also be re-assembled each S phase to incorporate newly replicated sister chromatids. The replication fork is the one complex that potentially interacts with every nucleotide of the genome, providing a mechanism to couple chromatin assembly to S phase passage. Importantly, eukaryotic genomes contain regions of structurally distinct chromatin, such as heterochromatin, defined by distinct patterns of histone modification and specific protein associations. Heterochromatin is generally associated with repeated sequence elements near centromeres, telomeres and other sites. Evidence suggests that heterochromatin assembled during S phase supports the association of multiprotein complexes required for many chromosome transactions, including transcriptional silencing, sister-chromatid cohesion, and kinetochore function. These complexes are in turn essential for regulated gene expression, equal chromosome segregation and genomic stability. Intriguingly, recent studies indicate that these processes are linked to S phase by temporal mechanisms as well as by replication-dependent activities.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1538-4101
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
It's all in the timing: linking S phase to chromatin structure and chromosome dynamics.
pubmed:affiliation
Molecular and Cell Biology Laboratory, The Salk Institute, La Jolla, California, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't