Linked Life Data

12850529

Source:http://linkedlifedata.com/resource/pubmed/id/12850529

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-7-9
pubmed:abstractText
Transitional cell carcinoma is the second most common genitourinary malignancy in US and third most common cause of death among genitourinary tumors. Treatment options for bladder cancer include surgery, often combined with chemotherapy, radiation, and/or immunotherapy. The MVAC adjuvant chemotherapy regimen has been most widely used in locally invasive as well as metastatic disease. Only a proportion of patients at risk will respond to therapy. There is thus need to identify good responder patients for adjuvant therapy and to identify new targets to treat a greater range of patients. Based upon patient-specific aberrations in pathways or known markers, both existing and new therapies can be tailored to benefit patients based on the risk of progression and molecular alterations specific to a patient's tumor. Targeted therapy, therefore, is defined as therapy that targets mechanism and risk. Utilizing the available knowledge of the molecular biology of cell-cycle regulation, signal transduction, apoptosis, and angiogenesis in bladder cancer, we review the potential therapeutic targets for rational drug development. Finally, using bladder cancer as a model for translational research, requirements for a desired clinical trial are presented.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1040-8428
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
46 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S67-83
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Therapeutic approaches to bladder cancer: identifying targets and mechanisms.
pubmed:affiliation
Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA. cote_r@norsur.hsu.usc.edu
pubmed:publicationType
Journal Article, Review