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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0007600,
umls-concept:C0235974,
umls-concept:C0332157,
umls-concept:C0439590,
umls-concept:C0443199,
umls-concept:C0871261,
umls-concept:C0879636,
umls-concept:C1173436,
umls-concept:C1518174,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
2
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pubmed:dateCreated |
2003-7-9
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pubmed:abstractText |
Pancreatic cancer remains a devastating disease, with 95% of all patients diagnosed with the disease dying within 2 years. The combined therapy using Erbitux, gemcitabine, and radiation caused complete tumor regression using a nude mouse model inoculated with pancreatic MiaPaCa-2 cells but only a delay in tumor growth with BxPC-3. We investigated the effect of prolonged Erbitux treatment to the sensitivity to gemcitabine and/or radiation and the epidermal growth factor receptor (EGFR) signal transduction pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/BAX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/BCL2L1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cobalt Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxycytidine,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GRB2 Adaptor Protein,
http://linkedlifedata.com/resource/pubmed/chemical/GRB2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-X Protein,
http://linkedlifedata.com/resource/pubmed/chemical/cetuximab,
http://linkedlifedata.com/resource/pubmed/chemical/gemcitabine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
274-83
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12850474-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12850474-Adenocarcinoma,
pubmed-meshheading:12850474-Antibodies, Monoclonal,
pubmed-meshheading:12850474-Apoptosis,
pubmed-meshheading:12850474-Cell Division,
pubmed-meshheading:12850474-Cobalt Radioisotopes,
pubmed-meshheading:12850474-Deoxycytidine,
pubmed-meshheading:12850474-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:12850474-Epidermal Growth Factor,
pubmed-meshheading:12850474-Flow Cytometry,
pubmed-meshheading:12850474-GRB2 Adaptor Protein,
pubmed-meshheading:12850474-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12850474-Humans,
pubmed-meshheading:12850474-Immunosorbent Techniques,
pubmed-meshheading:12850474-Iodine Radioisotopes,
pubmed-meshheading:12850474-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12850474-Pancreatic Neoplasms,
pubmed-meshheading:12850474-Proteins,
pubmed-meshheading:12850474-Proto-Oncogene Proteins,
pubmed-meshheading:12850474-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:12850474-Receptor, Epidermal Growth Factor,
pubmed-meshheading:12850474-Tumor Cells, Cultured,
pubmed-meshheading:12850474-bcl-2-Associated X Protein,
pubmed-meshheading:12850474-bcl-X Protein
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pubmed:year |
2003
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pubmed:articleTitle |
Differential responses by pancreatic carcinoma cell lines to prolonged exposure to Erbitux (IMC-C225) anti-EGFR antibody.
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pubmed:affiliation |
Division of General Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294-0016, USA.
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pubmed:publicationType |
Journal Article
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