12848784

Source:http://linkedlifedata.com/resource/pubmed/id/12848784

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0020317, umls-concept:C0057223, umls-concept:C0059563, umls-concept:C0074554, umls-concept:C0086418, umls-concept:C0127400, umls-concept:C1332830, umls-concept:C1373178
pubmed:issue	1
pubmed:dateCreated	2003-7-9
pubmed:abstractText	To identify the cytochrome P450 (CYP) isoforms responsible for the metabolism of simvastatin hydroxy acid (SVA), the most potent metabolite of simvastatin (SV).
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/12848784-10976657, http://linkedlifedata.com/resource/pubmed/commentcorrection/12848784-11753271, http://linkedlifedata.com/resource/pubmed/commentcorrection/12848784-12023536, http://linkedlifedata.com/resource/pubmed/commentcorrection/12848784-12386136, http://linkedlifedata.com/resource/pubmed/commentcorrection/12848784-12426523, http://linkedlifedata.com/resource/pubmed/commentcorrection/12848784-1602384, http://linkedlifedata.com/resource/pubmed/commentcorrection/12848784-1971563, http://linkedlifedata.com/resource/pubmed/commentcorrection/12848784-7720520, http://linkedlifedata.com/resource/pubmed/commentcorrection/12848784-7923194, http://linkedlifedata.com/resource/pubmed/commentcorrection/12848784-9217719, http://linkedlifedata.com/resource/pubmed/commentcorrection/12848784-9321523, http://linkedlifedata.com/resource/pubmed/commentcorrection/12848784-9542477
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7503323
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2D6, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A, http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases, N-Demethylating, http://linkedlifedata.com/resource/pubmed/chemical/Simvastatin
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	0306-5251
pubmed:author	pubmed-author:MaBennettB, pubmed-author:PrueksaritanontThomayantT, pubmed-author:YuNathanN
pubmed:issnType	Print
pubmed:volume	56
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	120-4
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:12848784-Aryl Hydrocarbon Hydroxylases, pubmed-meshheading:12848784-Cytochrome P-450 CYP2D6, pubmed-meshheading:12848784-Cytochrome P-450 CYP3A, pubmed-meshheading:12848784-Humans, pubmed-meshheading:12848784-Liver, pubmed-meshheading:12848784-Microsomes, pubmed-meshheading:12848784-Oxidoreductases, N-Demethylating, pubmed-meshheading:12848784-Simvastatin
pubmed:year	2003
pubmed:articleTitle	The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6.
pubmed:affiliation	Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA. thomayant_prueksaritanont@merck.com
pubmed:publicationType	Journal Article