12847684

Source:http://linkedlifedata.com/resource/pubmed/id/12847684

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003873, umls-concept:C0019409, umls-concept:C0033268, umls-concept:C0079189, umls-concept:C0087111, umls-concept:C0333348, umls-concept:C0623362, umls-concept:C0663914, umls-concept:C1514873
pubmed:issue	7
pubmed:dateCreated	2003-7-8
pubmed:abstractText	To investigate the potential role of IkappaB kinase 1 (IKK-1) and IKK-2 in the regulation of nuclear factor kappaB (NF-kappaB) activation and the expression of tumor necrosis factor alpha (TNFalpha), as well as interleukin-1beta (IL-1beta), IL-6, IL-8, vascular endothelial growth factor (VEGF), and matrix metalloproteinases (MMPs), in rheumatoid arthritis (RA).
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0370605
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/CHUK protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Collagenases, http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors, http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Kinase, http://linkedlifedata.com/resource/pubmed/chemical/IKBKB protein, human, http://linkedlifedata.com/resource/pubmed/chemical/IKBKE protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8, http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides, http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines, http://linkedlifedata.com/resource/pubmed/chemical/MMP13 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 1, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 13, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 3, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases, http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha, http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A, http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	0004-3591
pubmed:author	pubmed-author:AndreakosEvangelosE, pubmed-author:BrennanFionula MFM, pubmed-author:FeldmannMarcM, pubmed-author:FoxwellBrian MBM, pubmed-author:KiriakidisSerafimS, pubmed-author:MonacoClaudiaC, pubmed-author:PaleologEwaE, pubmed-author:SmithCliveC, pubmed-author:de MartinRainerR
pubmed:issnType	Print
pubmed:volume	48
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1901-12
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:12847684-Arthritis, Rheumatoid, pubmed-meshheading:12847684-Cells, Cultured, pubmed-meshheading:12847684-Collagenases, pubmed-meshheading:12847684-Cytokines, pubmed-meshheading:12847684-Endothelial Growth Factors, pubmed-meshheading:12847684-Endothelium, Vascular, pubmed-meshheading:12847684-Fibroblasts, pubmed-meshheading:12847684-Humans, pubmed-meshheading:12847684-I-kappa B Kinase, pubmed-meshheading:12847684-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:12847684-Interleukin-1, pubmed-meshheading:12847684-Interleukin-6, pubmed-meshheading:12847684-Interleukin-8, pubmed-meshheading:12847684-Lipopolysaccharides, pubmed-meshheading:12847684-Lymphokines, pubmed-meshheading:12847684-Macrophages, pubmed-meshheading:12847684-Matrix Metalloproteinase 1, pubmed-meshheading:12847684-Matrix Metalloproteinase 13, pubmed-meshheading:12847684-Matrix Metalloproteinase 2, pubmed-meshheading:12847684-Matrix Metalloproteinase 3, pubmed-meshheading:12847684-Matrix Metalloproteinases, pubmed-meshheading:12847684-Monocytes, pubmed-meshheading:12847684-NF-kappa B, pubmed-meshheading:12847684-Protein-Serine-Threonine Kinases, pubmed-meshheading:12847684-Skin, pubmed-meshheading:12847684-Synovial Membrane, pubmed-meshheading:12847684-Tumor Necrosis Factor-alpha, pubmed-meshheading:12847684-Umbilical Veins, pubmed-meshheading:12847684-Vascular Endothelial Growth Factor A, pubmed-meshheading:12847684-Vascular Endothelial Growth Factors
pubmed:year	2003
pubmed:articleTitle	Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.
pubmed:affiliation	Kennedy Institute of Rheumatology, Imperial College of Science, Technology and Medicine, London, UK.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't