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rdf:type |
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lifeskim:mentions |
umls-concept:C0008018,
umls-concept:C0011615,
umls-concept:C0014520,
umls-concept:C0022567,
umls-concept:C0026484,
umls-concept:C0030685,
umls-concept:C0033684,
umls-concept:C0162638,
umls-concept:C0205263,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1261552,
umls-concept:C1283071,
umls-concept:C1963578,
umls-concept:C2612117,
umls-concept:C2936223
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pubmed:issue |
2
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pubmed:dateCreated |
2003-7-8
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pubmed:abstractText |
Activation and skin-selective homing of T cells and their effector functions in the skin represent sequential immunological events in the pathogenesis of atopic dermatitis (AD). Apoptosis of keratinocytes, induced mainly by T cells and mediated by IFN-gamma and Fas, is the essential pathogenetic event in eczema formation. Keratinocyte apoptosis appears as activation-induced cell death in AD. By IFN-gamma stimulation, chemokines such as IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant are strongly up-regulated in keratinocytes. These chemokines attract T cells bearing the specific receptor CXCR3, which is highly expressed on T cells isolated from skin biopsies of AD patients. Accordingly, an increased T cell chemotaxis was observed toward IFN-gamma-treated keratinocytes. Supporting these findings, enhanced IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant expression was observed in lesional AD skin by immunohistochemical staining. These results indicate a second step of chemotaxis inside the skin after transendothelial migration of the inflammatory cells. Keratinocytes undergoing apoptosis in acute eczematous lesions release chemokines that attract more T cells toward the epidermis, which may further augment the inflammation and keratinocyte apoptosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CXCL11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCL9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCR3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL10,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL11,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL9,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1078-84
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12847282-Adult,
pubmed-meshheading:12847282-Aged,
pubmed-meshheading:12847282-Apoptosis,
pubmed-meshheading:12847282-Cell Line,
pubmed-meshheading:12847282-Cell Movement,
pubmed-meshheading:12847282-Cells, Cultured,
pubmed-meshheading:12847282-Chemokine CXCL10,
pubmed-meshheading:12847282-Chemokine CXCL11,
pubmed-meshheading:12847282-Chemokine CXCL9,
pubmed-meshheading:12847282-Chemokines, CXC,
pubmed-meshheading:12847282-Chemotaxis, Leukocyte,
pubmed-meshheading:12847282-Dermatitis, Atopic,
pubmed-meshheading:12847282-Endothelium,
pubmed-meshheading:12847282-Epidermis,
pubmed-meshheading:12847282-Humans,
pubmed-meshheading:12847282-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:12847282-Interferon-gamma,
pubmed-meshheading:12847282-Keratinocytes,
pubmed-meshheading:12847282-Middle Aged,
pubmed-meshheading:12847282-Receptors, CXCR3,
pubmed-meshheading:12847282-Receptors, Chemokine,
pubmed-meshheading:12847282-T-Lymphocyte Subsets,
pubmed-meshheading:12847282-Tumor Necrosis Factor-alpha,
pubmed-meshheading:12847282-Up-Regulation
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pubmed:year |
2003
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pubmed:articleTitle |
A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis.
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pubmed:affiliation |
Swiss Institute of Allergy and Asthma Research, Davos, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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