| pubmed-article:12847258 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12847258 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:12847258 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:12847258 | lifeskim:mentions | umls-concept:C0682638 | lld:lifeskim |
| pubmed-article:12847258 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:12847258 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:12847258 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:12847258 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:12847258 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12847258 | pubmed:dateCreated | 2003-7-8 | lld:pubmed |
| pubmed-article:12847258 | pubmed:abstractText | It has been proposed that the gamma-herpesviruses maintain lifelong latency in B cells by gaining entry into the memory B cell pool and taking advantage of host mechanisms for maintaining these cells. We directly tested this hypothesis by kinetically monitoring viral latency in CD40(+) and CD40(-) B cells from CD40(+)CD40(-) mixed bone marrow chimera mice after infection with a murine gamma-herpesvirus, MHV-68. CD40(+) B cells selectively entered germinal centers and differentiated into memory B cells. Importantly, latency was progressively lost in the CD40(-) B cells and preferentially maintained in the long-lived, isotype-switched CD40(+) B cells. These data directly demonstrate viral exploitation of the normal B cell differentiation pathway to maintain latency. | lld:pubmed |
| pubmed-article:12847258 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12847258 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12847258 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12847258 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12847258 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12847258 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12847258 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12847258 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12847258 | pubmed:author | pubmed-author:RandallTroy... | lld:pubmed |
| pubmed-article:12847258 | pubmed:author | pubmed-author:BlackmanMarci... | lld:pubmed |
| pubmed-article:12847258 | pubmed:author | pubmed-author:FlañoEmilioE | lld:pubmed |
| pubmed-article:12847258 | pubmed:author | pubmed-author:WoodlandDavid... | lld:pubmed |
| pubmed-article:12847258 | pubmed:author | pubmed-author:KimIn-JeongIJ | lld:pubmed |
| pubmed-article:12847258 | pubmed:author | pubmed-author:LundFrances... | lld:pubmed |
| pubmed-article:12847258 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12847258 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12847258 | pubmed:volume | 171 | lld:pubmed |
| pubmed-article:12847258 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12847258 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12847258 | pubmed:pagination | 886-92 | lld:pubmed |
| pubmed-article:12847258 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12847258 | pubmed:meshHeading | pubmed-meshheading:12847258... | lld:pubmed |
| pubmed-article:12847258 | pubmed:meshHeading | pubmed-meshheading:12847258... | lld:pubmed |
| pubmed-article:12847258 | pubmed:meshHeading | pubmed-meshheading:12847258... | lld:pubmed |
| pubmed-article:12847258 | pubmed:meshHeading | pubmed-meshheading:12847258... | lld:pubmed |
| pubmed-article:12847258 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12847258 | pubmed:articleTitle | Maintenance of long term gamma-herpesvirus B cell latency is dependent on CD40-mediated development of memory B cells. | lld:pubmed |
| pubmed-article:12847258 | pubmed:affiliation | Trudeau Institute, Saranac Lake, NY 12983, USA. | lld:pubmed |
| pubmed-article:12847258 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12847258 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12847258 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12847258 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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