Source:http://linkedlifedata.com/resource/pubmed/id/12847258
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2003-7-8
|
| pubmed:abstractText |
It has been proposed that the gamma-herpesviruses maintain lifelong latency in B cells by gaining entry into the memory B cell pool and taking advantage of host mechanisms for maintaining these cells. We directly tested this hypothesis by kinetically monitoring viral latency in CD40(+) and CD40(-) B cells from CD40(+)CD40(-) mixed bone marrow chimera mice after infection with a murine gamma-herpesvirus, MHV-68. CD40(+) B cells selectively entered germinal centers and differentiated into memory B cells. Importantly, latency was progressively lost in the CD40(-) B cells and preferentially maintained in the long-lived, isotype-switched CD40(+) B cells. These data directly demonstrate viral exploitation of the normal B cell differentiation pathway to maintain latency.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
171
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
886-92
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| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:12847258-3T3 Cells,
pubmed-meshheading:12847258-Animals,
pubmed-meshheading:12847258-Antigens, CD40,
pubmed-meshheading:12847258-B-Lymphocyte Subsets,
pubmed-meshheading:12847258-Bone Marrow Cells,
pubmed-meshheading:12847258-Bone Marrow Transplantation,
pubmed-meshheading:12847258-Cell Differentiation,
pubmed-meshheading:12847258-Cell Survival,
pubmed-meshheading:12847258-Gammaherpesvirinae,
pubmed-meshheading:12847258-Germinal Center,
pubmed-meshheading:12847258-Herpesviridae Infections,
pubmed-meshheading:12847258-Immunoglobulin Class Switching,
pubmed-meshheading:12847258-Immunologic Memory,
pubmed-meshheading:12847258-Lymphocyte Activation,
pubmed-meshheading:12847258-Mice,
pubmed-meshheading:12847258-Mice, Inbred C57BL,
pubmed-meshheading:12847258-Mice, Knockout,
pubmed-meshheading:12847258-Radiation Chimera,
pubmed-meshheading:12847258-Virus Latency
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Maintenance of long term gamma-herpesvirus B cell latency is dependent on CD40-mediated development of memory B cells.
|
| pubmed:affiliation |
Trudeau Institute, Saranac Lake, NY 12983, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|