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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-7-8
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pubmed:abstractText |
Cytochrome P450 1A1 plays a major role in the bioactivation of a number of tobacco procarcinogens. Much interest has focused on a polymorphism in exon 7 of the CYP1A1 gene which has been associated with a more inducible form of the enzyme. However, past results of its association with lung cancer have been inconsistent, especially in Caucasians. We carried out a pooled analysis of the data submitted to the Genetic Susceptibility to Environmental Carcinogens (GSEC) database to further investigate this association and, especially, to examine the modifying effects of smoking status and race.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0957-5243
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pubmed:author |
pubmed-author:BenhamouSimoneS,
pubmed-author:BouchardyChristineC,
pubmed-author:CascorbiIngolfI,
pubmed-author:ClapperMargie LML,
pubmed-author:GarteSeymourS,
pubmed-author:GuoChuanfaC,
pubmed-author:HaugenAageA,
pubmed-author:Ingelman-SundbergMagnusM,
pubmed-author:KiharaMasahiroM,
pubmed-author:Le MarchandLoïcL,
pubmed-author:RannugAgnetaA,
pubmed-author:RybergDavidD,
pubmed-author:StückerIsabelleI,
pubmed-author:SugimuraHaruhikoH,
pubmed-author:TaioliEmanuelaE
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
339-46
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12846365-Adenocarcinoma,
pubmed-meshheading:12846365-Aged,
pubmed-meshheading:12846365-Carcinogens, Environmental,
pubmed-meshheading:12846365-Carcinoma, Squamous Cell,
pubmed-meshheading:12846365-Case-Control Studies,
pubmed-meshheading:12846365-Continental Population Groups,
pubmed-meshheading:12846365-Cytochrome P-450 CYP1A1,
pubmed-meshheading:12846365-Exons,
pubmed-meshheading:12846365-Female,
pubmed-meshheading:12846365-Humans,
pubmed-meshheading:12846365-Logistic Models,
pubmed-meshheading:12846365-Lung Neoplasms,
pubmed-meshheading:12846365-Male,
pubmed-meshheading:12846365-Middle Aged,
pubmed-meshheading:12846365-Odds Ratio,
pubmed-meshheading:12846365-Polymorphism, Genetic,
pubmed-meshheading:12846365-Risk Factors,
pubmed-meshheading:12846365-Sex Factors,
pubmed-meshheading:12846365-Smoking,
pubmed-meshheading:12846365-United States
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pubmed:year |
2003
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pubmed:articleTitle |
Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States).
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pubmed:affiliation |
Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA. loic@crch.hawaii.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Meta-Analysis
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