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rdf:type |
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lifeskim:mentions |
umls-concept:C0178324,
umls-concept:C0871261,
umls-concept:C1333707,
umls-concept:C1514873,
umls-concept:C1527148,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692,
umls-concept:C2936380
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pubmed:issue |
10
|
|
pubmed:dateCreated |
2003-10-13
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|
pubmed:abstractText |
Neointima formation occurs in arteries in response to mechanical or chemical injury and is responsible for substantial morbidity. In this work, the role of the intracellular linker protein Grb2 in the pathogenesis of neointima formation was examined. Grb2 is a critical signaling protein that facilitates the activation of the small GTPase ras by receptor tyrosine kinases.
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pubmed:grant |
|
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1788-93
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12842846-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12842846-Animals,
pubmed-meshheading:12842846-Aorta,
pubmed-meshheading:12842846-Arteriosclerosis,
pubmed-meshheading:12842846-Carotid Arteries,
pubmed-meshheading:12842846-Carotid Artery Injuries,
pubmed-meshheading:12842846-Cell Division,
pubmed-meshheading:12842846-Cells, Cultured,
pubmed-meshheading:12842846-Disease Models, Animal,
pubmed-meshheading:12842846-GRB2 Adaptor Protein,
pubmed-meshheading:12842846-Mice,
pubmed-meshheading:12842846-Mice, Knockout,
pubmed-meshheading:12842846-Muscle, Smooth, Vascular,
pubmed-meshheading:12842846-Proteins,
pubmed-meshheading:12842846-Rats,
pubmed-meshheading:12842846-Signal Transduction,
pubmed-meshheading:12842846-Tunica Intima,
pubmed-meshheading:12842846-Vascular Diseases
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pubmed:year |
2003
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pubmed:articleTitle |
Grb2 is required for the development of neointima in response to vascular injury.
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pubmed:affiliation |
Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
