Source:http://linkedlifedata.com/resource/pubmed/id/12842307
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2003-7-4
|
| pubmed:abstractText |
A common functional polymorphism, G1947A, of the catechol-O-methyltransferase (COMT) enzyme has gained interest in schizophrenia research because of its critical involvement in cortical dopamine catabolism and frontal lobe function. An assumed mechanism of dopamine is the reduction of noise in prefrontal neural networks during information processing. Therefore, the hypothesis was tested whether a variation of the COMT genotype is associated with prefrontal noise, which is in part reflected by the frontal P300 amplitude. It was predicted that homozygous Met allele carriers have a lower frontal P300 amplitude.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0006-3223
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
54
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
40-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12842307-Acoustic Stimulation,
pubmed-meshheading:12842307-Adult,
pubmed-meshheading:12842307-Alleles,
pubmed-meshheading:12842307-Brain,
pubmed-meshheading:12842307-Case-Control Studies,
pubmed-meshheading:12842307-Catechol O-Methyltransferase,
pubmed-meshheading:12842307-Event-Related Potentials, P300,
pubmed-meshheading:12842307-Evoked Potentials, Auditory,
pubmed-meshheading:12842307-Female,
pubmed-meshheading:12842307-Genotype,
pubmed-meshheading:12842307-Humans,
pubmed-meshheading:12842307-Male,
pubmed-meshheading:12842307-Methionine,
pubmed-meshheading:12842307-Middle Aged,
pubmed-meshheading:12842307-Polymorphism, Single Nucleotide,
pubmed-meshheading:12842307-Prefrontal Cortex,
pubmed-meshheading:12842307-Schizophrenia,
pubmed-meshheading:12842307-Valine
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Association of the G1947A COMT (Val(108/158)Met) gene polymorphism with prefrontal P300 during information processing.
|
| pubmed:affiliation |
Laboratory for Clinical Psychophysiology, Department of Psychiatry, Free University, Berlin, Germany and National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|