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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6B
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pubmed:dateCreated |
1993-4-9
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pubmed:abstractText |
The prediction of prognosis in cervical carcinomas solely by histological examination is doubtful. Our study was undertaken to evaluate whether Cytokeratin 5D3, Cytokeratin high molecular weight (HMW), Cytokeratin AE1/AE3, Carcinoembryonic Antigen (CEA) and CA 19.9 could have a prognostic value in primarily irradiated stage FIGO III cervical cancer. We investigated 45 pretreatment punch biopsies of cervical cancer stage FIGO III. All patients underwent a combined standardised primary irradiation treatment. In the cases with expression of Cytokeratin AE1/AE3 survival was significantly better than in cases without expression. The expression of CEA also had a significantly positive effect on survival. The best prognosis was found in cases with coexpression of AE1/AE3 and CEA (Wilcoxon p = 0.006, log-Rank p = 0.03). The other investigated tumor associated antigen and intermediate filaments did not correlate with survival. The application of Cytokeratin AE1/AE3 and CEA allows a prediction of prognosis in patients with stage FIGO III cervical cancer undergoing irradiation treatment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2017-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1284198-Adenocarcinoma,
pubmed-meshheading:1284198-Antibodies, Monoclonal,
pubmed-meshheading:1284198-Antigens, Tumor-Associated, Carbohydrate,
pubmed-meshheading:1284198-Biopsy, Needle,
pubmed-meshheading:1284198-Carcinoembryonic Antigen,
pubmed-meshheading:1284198-Carcinoma, Squamous Cell,
pubmed-meshheading:1284198-Female,
pubmed-meshheading:1284198-Humans,
pubmed-meshheading:1284198-Immunohistochemistry,
pubmed-meshheading:1284198-Intermediate Filament Proteins,
pubmed-meshheading:1284198-Keratins,
pubmed-meshheading:1284198-Middle Aged,
pubmed-meshheading:1284198-Neoplasm Staging,
pubmed-meshheading:1284198-Prognosis,
pubmed-meshheading:1284198-Survival Analysis,
pubmed-meshheading:1284198-Tumor Markers, Biological,
pubmed-meshheading:1284198-Uterine Cervical Neoplasms
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pubmed:articleTitle |
Immunohistochemistry in stage FIGO III cervical cancer: prognostic value of tumor associated antigens and intermediate filaments.
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pubmed:affiliation |
II. Department of Obstetrics and Gynecology, University of Vienna, Austria.
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pubmed:publicationType |
Journal Article
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