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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1993-3-25
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pubmed:abstractText |
Sera of patients with myocarditis and dilated cardiomyopathy contain stimulatory autoantibodies directed specifically against the beta 1-adrenergic receptor. The binding of the antibodies could be localized to either the first or the second extracellular loop of the beta 1-adrenoceptor. In 73% of the cases investigated the antibodies recognized the second extracellular loop. The agonistic effects of the antibodies were abolished by beta-adrenergic antagonists. Furthermore, the antagonists were able to remove the antibodies from their binding sites.
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pubmed:language |
ger
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0300-5860
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81 Suppl 4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-83
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1283934-Adrenergic beta-Antagonists,
pubmed-meshheading:1283934-Animals,
pubmed-meshheading:1283934-Autoantibodies,
pubmed-meshheading:1283934-Binding Sites, Antibody,
pubmed-meshheading:1283934-Cardiomyopathy, Dilated,
pubmed-meshheading:1283934-Cells, Cultured,
pubmed-meshheading:1283934-Epitopes,
pubmed-meshheading:1283934-Heart Rate,
pubmed-meshheading:1283934-Humans,
pubmed-meshheading:1283934-Myocardial Contraction,
pubmed-meshheading:1283934-Myocarditis,
pubmed-meshheading:1283934-Myocardium,
pubmed-meshheading:1283934-Rats,
pubmed-meshheading:1283934-Rats, Wistar,
pubmed-meshheading:1283934-Receptors, Adrenergic, beta
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pubmed:year |
1992
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pubmed:articleTitle |
[Autoantibodies against the beta 1-adrenergic receptor in myocarditis and dilated cardiomyopathy: localization of two epitopes].
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pubmed:affiliation |
Max Delbrück Centrum für molekulare Medizin, Berlin.
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pubmed:publicationType |
Journal Article,
English Abstract
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