Linked Life Data

12837016

Source:http://linkedlifedata.com/resource/pubmed/id/12837016

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-7-2
pubmed:abstractText
Klein and Riso proposed several alternative models explaining the causes of comorbidity between two disorders (KR models). For each comorbidity model, they also presented a set of predictions for comparing the prevalence of disorder A-only, disorder B-only, and disorder AB (i.e., both disorders) among the relatives of probands with A-only, B-only, AB and controls (i.e., the KR predictions). Neale and Kendler provided the quantitative expectations for these prevalences (i.e., the NK models) and suggested biometric model fitting as an alternative way of testing comorbidity models. Neale and Kendler also suggested that the KR predictions have limited use because variations in the model parameters may lead to different predictions. We tested the KR predictions on two sets of data simulated under the assumptions of the KR/NK models. The results predicted by Klein and Riso and the results derived from the simulated datasets matched in most cases, but there were several notable discrepancies between the two sets of results. First, these discrepancies may be due to variations in the model parameters although the KR predictions are valid tests of the model for some model parameter sets. Second, several KR predictions may not be valid because they do not consider the necessary conditions for the diagnosis of A-only and B-only or alternative routes to comorbidity that are not hypothesized in their comorbidity model, including the fact that some comorbid cases will result by chance in all comorbidity models.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0001-8244
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
257-69
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
The validity of analyses testing the etiology of comorbidity between two disorders: comparisons of disorder prevalences in families.
pubmed:affiliation
Department of Psychology, Institute for Behavioral Genetics, Campus Box 447, University of Colorado, Boulder, Colorado 80309, USA. soo.rhee@colorado.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.