Linked Life Data

1283356

Source:http://linkedlifedata.com/resource/pubmed/id/1283356

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-2-26
pubmed:abstractText
Current treatment options for acquired-immunodeficiency syndrome (AIDS)-related non-Hodgkin's lymphoma (NHL) are unsatisfactory because of excessive toxicity rates and frequent recurrence of lymphoma. In this phase II study, we evaluated a novel 12 week chemotherapy program with respect to feasibility, toxicity and therapeutic results. Thirty HIV-seropositive patients with intermediate grade or small non-cleaved cell NHL received a 12 week program of weekly intravenous and oral chemotherapy consisting of etoposide, adriamycin, cyclophosphamide, bleomycin, vincristine, methotrexate and prednisone as well as biweekly intrathecal cytosine arabinoside. Prophylaxis against Pneumocystis carinii pneumonia (PCP) and candida were given routinely. The overall objective response rate was 73% with 33% complete responders. The time to progression for those stable or responding was 9.4 months. Five of 10 complete responders are well and free of disease 13.2 to 24.5 months from diagnosis. Median survival for the 30 patients was 8.1 months. NHL was the most common cause of death (13/22); opportunistic infection caused only one death (cryptococcal meningitis). Only 1 case of PCP occurred. The major toxicity was neutropenia. In conclusion this regimen resulted in response rates similar to other reports with acceptable toxicity and a very low incidence of PCP. Relapse of NHL remains a major challenge, however, and further studies are needed. Routine PCP prophylaxis should be incorporated into new trials of therapy for AIDS-related NHL.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1042-8194
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
213-20
pubmed:dateRevised
2007-9-4
pubmed:meshHeading
pubmed-meshheading:1283356-AIDS-Related Opportunistic Infections, pubmed-meshheading:1283356-Adult, pubmed-meshheading:1283356-Aged, pubmed-meshheading:1283356-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:1283356-Bacterial Infections, pubmed-meshheading:1283356-Bleomycin, pubmed-meshheading:1283356-Cyclophosphamide, pubmed-meshheading:1283356-Doxorubicin, pubmed-meshheading:1283356-Feasibility Studies, pubmed-meshheading:1283356-Female, pubmed-meshheading:1283356-Humans, pubmed-meshheading:1283356-Incidence, pubmed-meshheading:1283356-Leucovorin, pubmed-meshheading:1283356-Life Tables, pubmed-meshheading:1283356-Lymphoma, AIDS-Related, pubmed-meshheading:1283356-Male, pubmed-meshheading:1283356-Methotrexate, pubmed-meshheading:1283356-Middle Aged, pubmed-meshheading:1283356-Neutropenia, pubmed-meshheading:1283356-Pentamidine, pubmed-meshheading:1283356-Pneumonia, Pneumocystis, pubmed-meshheading:1283356-Prednisone, pubmed-meshheading:1283356-Remission Induction, pubmed-meshheading:1283356-Survival Analysis, pubmed-meshheading:1283356-Treatment Outcome, pubmed-meshheading:1283356-Vincristine
pubmed:year
1992
pubmed:articleTitle
Treatment of AIDS-related non-Hodgkin's lymphoma with a twelve week chemotherapy program.
pubmed:affiliation
Division of Medical Oncology, Toronto-Bayview Regional Cancer Centre, Ontario, Canada.
pubmed:publicationType
Journal Article, Clinical Trial, Clinical Trial, Phase II, Clinical Trial, Phase I