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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0032854,
umls-concept:C0033325,
umls-concept:C0185117,
umls-concept:C0205250,
umls-concept:C0441889,
umls-concept:C1334868,
umls-concept:C1336606,
umls-concept:C1336656,
umls-concept:C1458155,
umls-concept:C1561558,
umls-concept:C2698872,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2003-6-30
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pubmed:abstractText |
Amplification of DNA in certain chromosomal regions plays a crucial role in the development and progression of human malignancies, specifically when protooncogenic target genes within those amplicons are overexpressed. Comparative genomic hybridization studies have revealed frequent amplification at 20q in primary breast tumors. The aim of the current study was to identify specific genes in the 20q amplicon that were likely to have clinical significance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Topoisomerases, Type I,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/NCOA3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Coactivator 3,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TFAP2C protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-2,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 American Cancer Society.DOI 10.1002/cncr.11482
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
18-23
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12833450-Acetyltransferases,
pubmed-meshheading:12833450-Adult,
pubmed-meshheading:12833450-Aged,
pubmed-meshheading:12833450-Breast Neoplasms,
pubmed-meshheading:12833450-Carcinoma, Ductal, Breast,
pubmed-meshheading:12833450-DNA Topoisomerases, Type I,
pubmed-meshheading:12833450-DNA-Binding Proteins,
pubmed-meshheading:12833450-Female,
pubmed-meshheading:12833450-Gene Expression,
pubmed-meshheading:12833450-Histone Acetyltransferases,
pubmed-meshheading:12833450-Humans,
pubmed-meshheading:12833450-Middle Aged,
pubmed-meshheading:12833450-Nuclear Receptor Coactivator 3,
pubmed-meshheading:12833450-Oncogene Proteins,
pubmed-meshheading:12833450-Prognosis,
pubmed-meshheading:12833450-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12833450-Survival Analysis,
pubmed-meshheading:12833450-Trans-Activators,
pubmed-meshheading:12833450-Transcription Factor AP-2,
pubmed-meshheading:12833450-Transcription Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosis.
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pubmed:affiliation |
Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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