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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2003-7-30
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pubmed:abstractText |
Costimulation through the inducible costimulator (ICOS) and its ligand (ICOSL) is essential for T cell-dependent B cell responses, but the cellular and temporal dynamics underlying its in vivo effects are poorly defined. Here we have shown that Icosl(-/-) and Icos(-/-) mice had similar phenotypes and that ICOS-ICOSL costimulation modulated the early but not late phases of IgG1 affinity maturation. Exploiting the adoptive transfer of T or B cells from primed Icosl(-/-) mice, we provided genetic evidence that costimulation through ICOSL was essential for primary but not secondary helper T cell responses and for the control of both T and B cell activities, resulting in T cell-dependent IgG1 production.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1529-2908
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pubmed:author |
pubmed-author:BladtFriedhelmF,
pubmed-author:BouchardDenisD,
pubmed-author:BoucherLouis-MartinLM,
pubmed-author:DuncanGordonG,
pubmed-author:ErikssonUrsU,
pubmed-author:GajewskaBeata UBU,
pubmed-author:GronskiMatthewM,
pubmed-author:HoAlexandraA,
pubmed-author:JordanaManelM,
pubmed-author:MakTak WTW,
pubmed-author:OdermattBernhardB,
pubmed-author:OhashiPamela SPS,
pubmed-author:PawsonTonyT,
pubmed-author:PintilieMelaniaM,
pubmed-author:ShahinianArdaA,
pubmed-author:TafuriAnnaA,
pubmed-author:WakehamAndrewA,
pubmed-author:WhoriskyJohn SJS,
pubmed-author:YoshinagaSteve KSK
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
765-72
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12833154-Animals,
pubmed-meshheading:12833154-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:12833154-B-Lymphocytes,
pubmed-meshheading:12833154-Gene Deletion,
pubmed-meshheading:12833154-Immunoglobulin G,
pubmed-meshheading:12833154-Inducible T-Cell Co-Stimulator Ligand,
pubmed-meshheading:12833154-Inducible T-Cell Co-Stimulator Protein,
pubmed-meshheading:12833154-Lymphocyte Cooperation,
pubmed-meshheading:12833154-Mice,
pubmed-meshheading:12833154-Proteins,
pubmed-meshheading:12833154-T-Lymphocytes, Helper-Inducer
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pubmed:year |
2003
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pubmed:articleTitle |
Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses.
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pubmed:affiliation |
Advanced Medical Discovery Institute, and Ontario Cancer Institute, Department of Medical Biophysics , University of Toronto, Toronto, Ontario M5G 2C1, Canada. tmak@uhnres.utoronto.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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