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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-6-27
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pubmed:abstractText |
Apolipoprotein E-deficient mice (apoE(-/-)) on a regular diet become hypercholesterolemic and develop atherosclerosis, but endothelium-dependent relaxation remains undisturbed for up to 6 months. We investigated whether vasomotor dysfunction develops in aged apoE(-/-), whether the defect was systemic (hypercholesterolemia-dependent) or focal (plaque-related), and the effect of human apolipoprotein AI transgenesis (apoAI/E(-/-)).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
189-99
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12829190-Animals,
pubmed-meshheading:12829190-Aorta, Thoracic,
pubmed-meshheading:12829190-Apolipoprotein A-I,
pubmed-meshheading:12829190-Apolipoproteins E,
pubmed-meshheading:12829190-Arteriosclerosis,
pubmed-meshheading:12829190-Carotid Arteries,
pubmed-meshheading:12829190-Cholesterol,
pubmed-meshheading:12829190-Dose-Response Relationship, Drug,
pubmed-meshheading:12829190-Endothelium, Vascular,
pubmed-meshheading:12829190-Humans,
pubmed-meshheading:12829190-Hypolipoproteinemias,
pubmed-meshheading:12829190-Mice,
pubmed-meshheading:12829190-Mice, Inbred C57BL,
pubmed-meshheading:12829190-Mice, Transgenic,
pubmed-meshheading:12829190-Phenylephrine,
pubmed-meshheading:12829190-Vasoconstrictor Agents
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pubmed:year |
2003
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pubmed:articleTitle |
Plaque-associated endothelial dysfunction in apolipoprotein E-deficient mice on a regular diet. Effect of human apolipoprotein AI.
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pubmed:affiliation |
Division of Pharmacology (T2), University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium. herta.crauwels@ua.ac.be
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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