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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-6-27
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pubmed:abstractText |
The antihyperglycemic action of puerarin, purified from the roots of Pueraria lobata, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Bolus intravenous injection of puerarin decreased the plasma glucose concentrations in a dose-dependent manner in STZ-diabetic rats. Similar treatment with puerarin also decreased the plasma glucose in normal rats, although the effect was not as great as that in STZ-diabetic rats. Puerarin at the effective dose (15.0 mg/kg) significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. In the isolated soleus muscle of STZ-diabetic rats, puerarin enhanced the uptake of radioactive glucose in a concentration-dependent manner. Moreover, the mRNA and protein levels of the subtype 4 form of glucose transporter (GLUT4) in soleus muscle were increased after repeated intravenous administration of puerarin in STZ-diabetic rats for 3 days. These results suggest that puerarin can increase the glucose utilization to lower plasma glucose in diabetic rats lacking insulin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose Transporter Type 4,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflavones,
http://linkedlifedata.com/resource/pubmed/chemical/Monosaccharide Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Slc2a4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Streptozocin,
http://linkedlifedata.com/resource/pubmed/chemical/puerarin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0163-3864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
788-92
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12828463-Animals,
pubmed-meshheading:12828463-Blood Glucose,
pubmed-meshheading:12828463-Diabetes Mellitus, Experimental,
pubmed-meshheading:12828463-Disease Models, Animal,
pubmed-meshheading:12828463-Dose-Response Relationship, Drug,
pubmed-meshheading:12828463-Glucose,
pubmed-meshheading:12828463-Glucose Transporter Type 4,
pubmed-meshheading:12828463-Hypoglycemic Agents,
pubmed-meshheading:12828463-Insulin,
pubmed-meshheading:12828463-Isoflavones,
pubmed-meshheading:12828463-Molecular Structure,
pubmed-meshheading:12828463-Monosaccharide Transport Proteins,
pubmed-meshheading:12828463-Muscle, Skeletal,
pubmed-meshheading:12828463-Muscle Proteins,
pubmed-meshheading:12828463-Plant Roots,
pubmed-meshheading:12828463-Plants, Medicinal,
pubmed-meshheading:12828463-Pueraria,
pubmed-meshheading:12828463-RNA, Messenger,
pubmed-meshheading:12828463-Rats,
pubmed-meshheading:12828463-Streptozocin,
pubmed-meshheading:12828463-Taiwan
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pubmed:year |
2003
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pubmed:articleTitle |
Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats.
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pubmed:affiliation |
Institute of Pharmacognosy, School of Pharmacy, Taipei Medical University, Taipei City, Taiwan 110-31.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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