Source:http://linkedlifedata.com/resource/pubmed/id/12826884
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2003-6-26
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| pubmed:abstractText |
The great majority of primary central nervous system lymphoma (PCNSL) is known to be of B-lineage, with T-cell PCNSL (T-PCNSL) accounting for <5%. We report an unusually high incidence of T-cell lymphoma among the PCNSLs originated in a large general-care hospital in the metropolitan Seoul area. PCNSLs (n = 42) accrued from April 1995 through June 2001 were reviewed for histologic and clinical features, and immunohistochemical staining was done for CD3, CD20, CD4, CD8, Bcl-6, and CD10. Clonal rearrangements of the TCR-gamma and IgH genes were studied with semi-nested PCR in all seven cases of T-PCNSL and seven of 35 B-cell PCNSL (B-PCNSL). Formalin-fixed, paraffin-embedded specimens were used in all these studies. By immunohistochemical staining and molecular studies, seven cases (16.7%) were diagnosed as T-PCNSL, each displaying clonal rearrangement of the TCR-gamma gene, and 35 (83.3%) as B-PCNSL. Radiologically, T-PCNSL was significantly correlated with the superficial and subcortical lobar location (p <0.001), solitary mass formation (p = 0.001), presence of rim enhancement (p <0.001), and peritumoral edema (p = 0.029). Involvement of cerebrospinal fluid was observed only in B-PCNSL (n = 17) but not in T-PCNSL (p = 0.010). Histologically, T-PCNSL was characterized by a population of mixed predominantly small- and occasionally medium-sized cells (p <0.001), which were loosely scattered without forming a solid mass (p = 0.024), and perivascular infiltration was frequent (p = 0.007), in contrast to predominantly large cells of B-PCNSL, i.e., diffuse large B-cell lymphoma (DLBCL), in which the cells tended to aggregate to form monomorphous sheets (p = 0.024). In T-PCNSL, staining for CD8 was positive in five, including one with coexpression of CD4, and two were negative for CD4 and CD8. Of 24 DLBCLs tested, the pattern of Bcl-6+ tumor cells was diffusely dense, similar to that of the germinal center in nine cases (37.5%), with coexpression of CD10 in three of the nine cases. T-PCNSL accounted for 16.7% of the PCNSLs; thus, in Korea it may not be as rare as previously known. The T-PCNSL presented with certain clinical and pathologic features that were distinct from B-PCNSL and displayed preponderance of CD8 expression. DLBCL of the germinal center B-cell derivation defined by bcl-6 expression comprised 37.5% of DLBCL of the brain.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Heavy Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0147-5185
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
27
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
919-28
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12826884-Adolescent,
pubmed-meshheading:12826884-Adult,
pubmed-meshheading:12826884-Aged,
pubmed-meshheading:12826884-Aged, 80 and over,
pubmed-meshheading:12826884-Antigens, CD,
pubmed-meshheading:12826884-Brain Neoplasms,
pubmed-meshheading:12826884-DNA, Neoplasm,
pubmed-meshheading:12826884-Female,
pubmed-meshheading:12826884-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:12826884-Humans,
pubmed-meshheading:12826884-Immunoenzyme Techniques,
pubmed-meshheading:12826884-Immunoglobulin Heavy Chains,
pubmed-meshheading:12826884-Korea,
pubmed-meshheading:12826884-Lymphoma, B-Cell,
pubmed-meshheading:12826884-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:12826884-Lymphoma, T-Cell, Peripheral,
pubmed-meshheading:12826884-Male,
pubmed-meshheading:12826884-Middle Aged,
pubmed-meshheading:12826884-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:12826884-Retrospective Studies,
pubmed-meshheading:12826884-Tumor Markers, Biological
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| pubmed:year |
2003
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| pubmed:articleTitle |
Primary central nervous system lymphoma in Korea: comparison of B- and T-cell lymphomas.
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| pubmed:affiliation |
Department of Diagnostic Pathology, Sungkyunkan University College of Medicine, Seoul, Korea.
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| pubmed:publicationType |
Journal Article
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