Linked Life Data

12826741

Source:http://linkedlifedata.com/resource/pubmed/id/12826741

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-6-26
pubmed:abstractText
Alzheimer's disease (AD) is the most frequent cause of dementia in elderly people. Different pathological pathways have been involved in the development of late-onset AD. Among them, numerous genes have been proposed as pathogenetic factors acting independently or interactively. It has been suggested that the cathepsin D gene (CTSD) is associated with late-onset AD. We analyzed an exonic polymorphism of the CTSD gene [C-->T (Ala-->Val) transition at position 224] in 142 AD patients and 120 controls. Our data indicate no significant association between this polymorphism and the risk of AD. Likewise there was no association between CTSD polymorphism and the apolipoprotein E genotype in the risk of developing AD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1420-8008
pubmed:author
pubmed:copyrightInfo
Copyright 2003 S. Karger AG, Basel
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-5
pubmed:dateRevised
2008-3-24
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease.
pubmed:affiliation
Department of Gerontology and Geriatrics, University of Perugia School of Medicine, Perugia, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't