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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-6-26
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pubmed:abstractText |
Synthetic siRNAs 21 to 23 nucleotides in length silence gene expression posttranscriptionally, and RNA interference targeting Fas protects mice from fulminant hepatitis. Fas-mediated apoptosis has also been implied in the mechanism of hepatocyte apoptosis upon allogenic hepatocyte transplantation (HTx), and blockade of Fas and Fas ligand interaction successfully promotes the repopulation of allogenic liver cells in recipient spleens. In the present study, we further investigated the protective effects of Fas silencing on allogeneic hepatocytes transplanted into mouse spleens.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0041-1345
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1594-5
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pubmed:dateRevised |
2004-12-15
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pubmed:meshHeading |
pubmed-meshheading:12826229-Animals,
pubmed-meshheading:12826229-Antigens, CD95,
pubmed-meshheading:12826229-Apoptosis,
pubmed-meshheading:12826229-Cell Death,
pubmed-meshheading:12826229-Cell Transplantation,
pubmed-meshheading:12826229-Graft Survival,
pubmed-meshheading:12826229-Green Fluorescent Proteins,
pubmed-meshheading:12826229-Hepatocytes,
pubmed-meshheading:12826229-Luminescent Proteins,
pubmed-meshheading:12826229-Mice,
pubmed-meshheading:12826229-Mice, Inbred BALB C,
pubmed-meshheading:12826229-Models, Animal,
pubmed-meshheading:12826229-RNA, Small Interfering,
pubmed-meshheading:12826229-Spleen,
pubmed-meshheading:12826229-Transfection,
pubmed-meshheading:12826229-Transplantation, Homologous
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pubmed:year |
2003
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pubmed:articleTitle |
Fas siRNA reduces apoptotic cell death of allogeneic-transplanted hepatocytes in mouse spleen.
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pubmed:affiliation |
Department of Surgery, Sun-Yat-Sen Memorial Hospital of Sun-Yat-Sen University of Medical Science, Guangzhou, China. gzsumsjw@yahoo.com.cn
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pubmed:publicationType |
Journal Article
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