rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
14
|
pubmed:dateCreated |
2003-6-26
|
pubmed:abstractText |
Novel 4-aryl-3-(hydroxyalkyl)quinoline-2-one derivatives were prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiological methods. The effect of these maxi-K openers on corporal smooth muscle was studied in vitro using isolated rabbit corpus cavernosum. From this study, a potent maxi-K opener was identified as an effective relaxant of rabbit corporal smooth muscle and shown to be active in an in vivo animal model of male erectile function.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0022-2623
|
pubmed:author |
pubmed-author:BoissardChristopher GCG,
pubmed-author:CookDeborahD,
pubmed-author:DingMinM,
pubmed-author:DworetzkySteven ISI,
pubmed-author:FanWenhongW,
pubmed-author:FlintKimK,
pubmed-author:GogginsGregory DGD,
pubmed-author:GribkoffValentin KVK,
pubmed-author:HewawasamPiyasenaP,
pubmed-author:LodgeNicholas JNJ,
pubmed-author:MyersRobert ARA,
pubmed-author:StarrettJohn EJEJr
|
pubmed:issnType |
Print
|
pubmed:day |
3
|
pubmed:volume |
46
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2819-22
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:12825925-Animals,
pubmed-meshheading:12825925-Blood Pressure,
pubmed-meshheading:12825925-Electric Stimulation,
pubmed-meshheading:12825925-Erectile Dysfunction,
pubmed-meshheading:12825925-Large-Conductance Calcium-Activated Potassium Channels,
pubmed-meshheading:12825925-Male,
pubmed-meshheading:12825925-Muscle, Smooth,
pubmed-meshheading:12825925-Muscle Relaxation,
pubmed-meshheading:12825925-Penile Erection,
pubmed-meshheading:12825925-Penis,
pubmed-meshheading:12825925-Potassium Channels, Calcium-Activated,
pubmed-meshheading:12825925-Pressure,
pubmed-meshheading:12825925-Quinolones,
pubmed-meshheading:12825925-Rabbits,
pubmed-meshheading:12825925-Rats,
pubmed-meshheading:12825925-Rats, Inbred F344,
pubmed-meshheading:12825925-Structure-Activity Relationship
|
pubmed:year |
2003
|
pubmed:articleTitle |
4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction.
|
pubmed:affiliation |
Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA. hewawasp@bms.com
|
pubmed:publicationType |
Journal Article,
In Vitro
|